AstraZeneca Shares Fall Most Since 2008 on Brilinta

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AstraZeneca Plc fell the most in more than two years in London trading after the U.K. drugmaker failed to win U.S. approval for a new blood thinner to rival Plavix, the world’s second-best selling drug.

The stock dropped 212 pence, or 6.7 percent, to 2,941 pence, the steepest decline since Nov. 21, 2008, and the worst performance today on the 18-company Bloomberg Europe Pharmaceutical Index.