Weight Loss Yo-Yo Effect Is Linked to Cell Memory in Study
A scientist uses a culture flask and pipette in a Danish research lab.
Photographer: Carsten Snejbjerg/BloombergHi, this is Naomi in Berlin, where the season of gingerbread and chocolate will soon threaten to reprogram everyone’s cells. More on that soon, but first...
Almost anyone who has ever been on a diet will be well aware of the unrelenting and dispiriting yo-yo effect of losing and then regaining weight. And while weight-loss drugs like Novo Nordisk’s Wegovy and Eli Lilly’s Zepbound have taken the world by storm, the rebound happens here too, as soon as most people stop taking the shots. Patients in two of Novo’s clinical trials regained most of the weight they’d lost within a year after stopping the medicine. A study of Zepbound also showed substantial weight regained.