Weight Loss From Eli Lilly’s Zepbound Reversed Slowly After Treatment Stopped

  • Those who halted taking Zepbound regained half of lost weight
  • Result shows ongoing use of drug is needed, study leader says
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People who stopped taking Eli Lilly & Co.’s Zepbound after about eight months regained half the weight they’d lost a year later, yet were significantly thinner than when they had started the obesity drug, according to a study.

Taking Zepbound for 36 weeks resulted in a 21% loss of body weight, according to the study published Monday in the Journal of the American Medical Association. But after 88 weeks, a group no longer taking the drug after the first 8 months had still lost 10% of their weight. Those who stayed on the drug the entire time lost an average of 25%.