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obi pharma inc (4174) Details

OBI Pharma, Inc. engages in the research of new drugs in Taiwan and internationally. The company, through its subsidiaries, is also involved in the biotechnology development; and investing and trading activities. The company was founded in 2002 and is based in Taipei, Taiwan.

Founded in 2002

obi pharma inc (4174) Top Compensated Officers

Chief Planner of Global Clinical Test
Total Annual Compensation: 4.2M
Compensation as of Fiscal Year 2016.
obi pharma inc
OBI Pharma, Inc. Announces OBI-3424 Results from the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics

OBI Pharma, Inc. announced the results of a patient-derived xenograft (PDX) model study of OBI-3424 in T-cell acute lymphoblastic leukemia (T-ALL), presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in Philadelphia, PA, USA. The study was supported by National Cancer Institute (NCI) grants CA199222 & CA199000, and conducted by the NCI Pediatric Preclinical Testing Consortium. Overall study results demonstrated that OBI-3424 was well-tolerated, with only a 2.8% toxicity rate in the drug-treated groups. OBI-3424 induced significant differences in EFS distribution compared to control in 9 of 9 (100%) of the evaluable patient-derived xenografts (PDXs). T-C values ranged from 17.1 to 65.2 days (T/C 2.3-14.0), and objective responses were observed in 8 of 9 PDXs (2 Complete responses, CRs; 6 Maintained CRs, MCRs). A significant reduction (P<0.0001) in bone marrow infiltration at Day 28 was observed in 4 of 6 evaluable T-ALL PDXs. The importance of AKR1C3 in the in vivo responses of ALL PDXs to OBI-3424 was verified using a B-cell precursor ALL PDX (ALL-11) that had been lentivirally transduced to stably overexpress AKR1C3 (ALL-11/1C3) compared with empty vector controls (ALL-11/EV). Mice engrafted with ALL-11/1C3 exhibited an MCR (T-C >37.3 days, T/C >3) compared with a CR for ALL-11/EV (T-C 21.1 days, T/C 2.5). Infiltration of ALL-11/1C3 cells into the murine bone marrow was significantly reduced at Day 28 in OBI-3424-treated compared to vehicle-treated mice (P<0.0001), but not to mice engrafted with ALL-11/EV.

OBI Pharma Announces Presentation on OBI-3424 at AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics

OBI Pharma, Inc. announced that new data, for OBI-3424 in vivo efficacy against patient-derived xenograft (PDX) models of T-cell acute lymphoblastic leukemia (T-ALL), will be presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in Philadelphia, Pennsylvania, USA, by Professor Richard B. Lock, PhD, Head of the Children's Cancer Institute's Leukemia Biology Program at the Lowy Cancer Research Centre in Sydney, Australia. The study was supported by National Cancer Institute (NCI) grants CA199222 & CA199000, and conducted by the NCI Pediatric Preclinical Testing Consortium. Poster presentation time: October 29, 2017, 12:30 p.m. -- 3:00 p.m. EDT Title: The AKR1C3-Activated Prodrug OBI-3424 Exerts Profound In Vivo Efficacy Against Preclinical Models of T-Cell Acute Lymphoblastic Leukemia (T-ALL); a Pediatric Preclinical Testing Consortium Study Session Title: Late Breaking Poster Session B Abstract number: LB-B16 Presenting author: Prof. Richard B. Lock, PhD, Head of the Children's Cancer Institute, Leukemia Biology Program, at the Lowy Cancer Research Centre, (Sydney, Australia) Location: Pennsylvania Convention Center, Hall E. Philadelphia, Pennsylvania, USA. About OBI-3424 OBI-3424 is a first-in-class novel small-molecule prodrug that selectively targets cancers that overexpress the enzyme aldo-keto reductase 1c3 (AKR1C3), and selectively releases a potent DNA alkylating agent in the presence of the AKR1C3 enzyme. This selective mode of activation distinguishes OBI-3424 from traditional alkylating agents, such as cyclophosphamide and ifosfamide, which are non-selective. AKR1C3 overexpression has been documented in a number of treatment-resistant and difficult to treat cancers including: hepatocellular carcinomas (HCC), castrate-resistant prostate cancer (CRPC) and T-cell acute lymphoblastic leukemia (T-ALL). Furthermore, individualized patient selection by staining for AKR1C3 overexpression by immunohistochemistry can be performed to identify patients with other tumor types most likely to respond to treatment with OBI-3424, offering the possibility for a streamlined clinical development strategy.OBI Pharma plans an Investigational New Drug (IND) application filing with the U.S. Food and Drug Administration (FDA) in early 2018.OBI Pharma has OBI-3424 worldwide rights with the exception of the following countries, of which Ascenta Pharma has rights: China, Hong Kong, Macao, Taiwan, Japan, South Korea, Singapore, Malaysia, Thailand, Turkey and India.

Abzena plc Signs Licensing Agreement with OBI Pharma

Abzena plc has signed a licensing agreement and a master services and clinical supply agreement with OBI Pharma. The licensing agreement is for Abzena's novel site-specific ThioBridge antibody drug conjugate (ADC) linker technology to develop OBI's proprietary ADC, OBI-999 and a series of further ADCs as potential treatments for cancer. ThioBridge links antibodies and other proteins to drugs. The technology platform is unique in its ability to maintain the stability of the antibody and a consistent Drug-to-Antibody Ratio (DAR), which provides a more uniform product. OBI-999 specifically targets cancer cells overexpressing the cancer antigen Globo H. The Globo series comprises a group of cancer-associated carbohydrate antigens including Globo H, SSEA3 and SSEA4 that are over-expressed in more than 14 types of cancers, including breast, lung, gastric and colorectal. By releasing the cytotoxic payload to the targeted cancer cells, the aim is to trigger cancer apoptosis while minimising the drug's toxicities to normal cells. OBI has observed encouraging results for OBI-999 in preclinical studies and plans to accelerate the development of OBI-999 and other Globo series ADCs. Phase I IND preparations are underway including Chemistry Manufacturing Control (CMC) planning and toxicology study design. Concurrent with the signing of the licence agreement, Abzena and OBI have entered into a Master Services and Clinical Supply Agreement for Abzena to provide OBI with further manufacturing process development and GMP manufacture of OBI-999 and further ADCs. Under the terms of this agreement, OBI will receive a worldwide exclusive licence to use the ThioBridge technology to research, develop and commercialize ADCs targeting the Globo series. Abzena will receive a small initial up-front payment from OBI and has the potential, subject to successful development, to receive up to £128 million, in aggregate, which may become payable upon achievement of certain development, regulatory and commercialisation milestones. In addition, Abzena will also receive royalties on sales of any approved ADC products that incorporate the ThioBridge™ technology.

 

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Price/Earnings NM Not Meaningful
Price/Sales 69,329.0x
Price/Book 5.2x
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TEV/Sales 57,510.1x
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