April 25, 2018 12:48 AM ET

Pharmaceuticals

Company Overview of Io Therapeutics, Inc.

Company Overview

Io Therapeutics, Inc., a biopharmaceutical company, develops and commercializes therapeutic compounds for cancer, and neurodegenerative and autoimmune diseases. The company offers retinoid and rexinoid molecule drugs for prostate, non small cell lung, breast, and pancreatic cancers; neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases, traumatic brain injury, and other diseases; and autoimmune diseases, including multiple sclerosis and others. Io Therapeutics, Inc. was founded in 2010 and is based in Santa Ana, California.

1805 East Garry Avenue

Suite 110

Santa Ana, CA 92705-5851

United States

Founded in 2010

Phone:

650-219-5973

Key Executives for Io Therapeutics, Inc.

Co-Founder, Executive Chairman and Chief Executive Officer
Co-Founder, President, Chief Scientific Officer and Director
Age: 68
Co-Founder, Director and Member of Scientific Advisory Board
Vice President of Business Development
Vice President of Regulatory Affairs
Compensation as of Fiscal Year 2017.

Io Therapeutics, Inc. Key Developments

Io Therapeutics, Inc. Reports Data Demonstrating of the Candidate Treatment for Multiple Sclerosis, IRX4204, Promotes Repair of Damaged Myelin

Io Therapeutics, Inc. has reported data demonstrating that the company's experimental rexinoid nuclear receptor (RXR) agonist compound, IRX4204, promotes repair of myelin in a mouse model of multiple sclerosis (MS). Myelin is a tissue in the brain and spinal cord which is damaged by an autoimmune process in MS, resulting in progressive disability and death. Finding new treatments, which promote repair of myelin is a major focus of current MS research. The company's data were presented at the 32nd Congress of The European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), currently being held in London, England. The reported studies were supported by funding from the US National Multiple Sclerosis Society's Fast Forward Program. In MS, autoimmune processes damage the myelin sheath surrounding nerve fibers, resulting in dysfunction of signal transmission in the brain and spinal cord. Myelin damage contributes to physical disability in MS patients. Many currently available treatments for MS target the autoimmune processes, but to date, none have been conclusively demonstrated to promote repair of damaged myelin in MS patients. The company has previously reported that IRX4204 has beneficial effects on autoimmunity, and protects against loss of neurons, in animal models of MS. The current data, showing that IRX4204 promotes repair of damaged myelin in an animal model of MS, demonstrates a third critically important mechanism of action of the drug as a promising potential treatment for MS.

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