December 11, 2017 7:03 AM ET

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Company Overview of Sapienza University of Rome

Company Overview

Sapienza University of Rome is an educational institution which offers bachelor's and master's degree, PhD, training, one to two year professional, and higher education courses. The institution provides courses in the fields of architecture, civil and industrial engineering, economics, informatics, statistics, law mathematics, physics, natural sciences, medicine, psychology, pharmacy, arts, humanities, political and communication science, and sociology. Additionally, it offers Italian language courses. Sapienza University of Rome was founded in 1303 and is based in Rome, Italy.

Piazzale Aldo Moro 5

Rome, RM 00185

Italy

Founded in 1303

Phone:

39 06 49911

Key Executives for Sapienza University of Rome

Director General
Compensation as of Fiscal Year 2017.

Sapienza University of Rome Key Developments

George Washington University, University of Perugia, and University of Rome Announce Discovery of New Cystic Fibrosis Drug

George Washington University (GW), the University of Perugia, and the University of Rome have discovered a new drug to treat and stop the progression of cystic fibrosis. Thymosin a1 (Ta1) is a novel therapeutic single molecule-based therapy that not only corrects genetic and tissue defects, but also significantly reduces inflammation seen in cystic fibrosis patients. Cystic fibrosis is the result of mutations in the gene encoding the protein called the cystic fibrosis transmembrane conductance regulator (CFTR), which is important to maintain chloride-channel activity affecting the salt and water balance in the lungs. This mutation results in a misfolded CFTR protein, and its premature degradation leads to impaired chloride permeability and persistent lung inflammation. Goldstein and co-authors Luigina Romani, Ph.D., M.D., at the University of Perugia and Enrico Garaci, M.D., at the University of Rome "San Raffaele," both in Italy, published their results in Nature Medicine. They report that Ta1, a synthetic version of a naturally occurring peptide first isolated from the thymus, corrects the multiple tissue defects found in the lungs and small intestines in a mouse model of cystic fibrosis, as well as the defects in the CFTR seen in cells isolated from cystic fibrosis patients. Ta1 not only significantly reduces the inflammation seen in cystic fibrosis, but also increases CFTR maturation, stability, and activity. Due to this two-pronged action, Ta1 offers a strong potential to be a single-molecule therapeutic agent to treat and stop the progression of cystic fibrosis. Goldstein and colleagues first isolated and characterized Ta1 as a biological response modifier with potent immune therapeutic activity in 1979. This research was done in large part at GW. Although the peptide is produced in small amounts in several peripheral lymphoid and non-lymphoid tissues, the highest concentrations of Ta1 are found in the thymus. Ta1, whose commercial name is Zadaxin, has been approved for clinical use for over 15 years in 35 countries in the treatment of patients with viral infections, immunodeficiency diseases, malignancies, and HIV/AIDS. Though not currently available in the US, it has an excellent safety profile and does not induce the side effects and toxicities commonly associated with most immunomodulatory agents.

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