May 23, 2018 4:58 PM ET


Company Overview of Idera Pharmaceuticals, Inc.

Company Overview

Idera Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, focuses on the discovery, development, and commercialization of oligonucleotide therapeutics for oncology and rare diseases in the United States. The company uses two drug discovery technology platforms to design and develop drug candidates, including toll-like receptor targeting technology and nucleic acid chemistry technology. Its drug candidates include IMO-2125, an agonist that is in Phase III clinical trial in combination with ipilimumab and pembrolizumab for the treatment of anti-PD-1 refractory metastatic melanoma; and which is in Phase Ib monotherapy trial in multiple tumor types for the treatment of refractory ...

167 Sidney Street

Cambridge, MA 02139

United States

Founded in 1989

62 Employees





Key Executives for Idera Pharmaceuticals, Inc.

Idera Pharmaceuticals, Inc. does not have any Key Executives recorded.

Idera Pharmaceuticals, Inc. Key Developments

Idera Pharmaceuticals, Inc. Reports Earnings Results for the First Quarter Ended March 31, 2018

Idera Pharmaceuticals, Inc. reported earnings results for the first quarter ended March 31, 2018. For the quarter, the company reported alliance revenue of $255,000 against $378,000 a year ago. Loss from operations was $20,280,000 against $15,188,000 a year ago. Net loss was $20,095,000 against $15,057,000 a year ago. Net loss per common share applicable to common stockholders - Basic and diluted was $0.10 against $0.10 a year ago.

Idera Pharmaceuticals Presents Pre-Clinical Data Demonstrating Potential for Tilsotolimod (IMO-2125) in Combination with Checkpoint Inhibitors at the American Association for Cancer Research (AACR) 2018 Annual Meeting

Idera Pharmaceuticals, Inc. is reporting pre-clinical data from a study evaluating a combination regimen that involved the TLR-9 agonist tilsotolimod (IMO-2125) and checkpoint inhibitors targeting two negative immune regulators, IDO-1 and PD-1 to eliminate established tumors in syngeneic tumor models at the AACR 2018 Annual Meeting being held in Chicago, IL. The key findings in Dr. Wang’s presentation were that intratumoral administration of tilsotolimod increases TIL infiltration and checkpoint expression in both injected and distant lesions creating a favorable tumor microenvironment to enhance the antitumor activity of checkpoint inhibitors. Specifically in this study, it was found that the combination of tilsotolimod with checkpoint inhibitors targeting IDO-1 and PD-1 induced maximal antitumor efficacy and eradicated large established tumors both treated and distant, in preclinical models compared to either agent alone as well as combinations of IDO-1 inhibitor and anti-PD-1. Tilsotolimod received orphan drug designation from the US Food and Drug Administration (FDA) in 2017 for the treatment of melanoma Stages IIb to IV. Tilsotolimod, in combination with ipilimumab, for PD-1 inhibitor refractory metastatic melanoma was granted fast track application by the FDA in 2017. Tilsotolimod is a toll-like receptor (TLR) 9 agonist that signals the immune system to create and activate cancer-fighting cells (T-cells). Currently approved immuno-oncology treatments for patients with metastatic melanoma, specifically check-point inhibitors, work for some but not all, as many patients’ immune response is missing or weak and thus they do not benefit from the checkpoint therapy making them so-called “refractory”. The combination of ipilimumab and tilsotolimod appears to activate an immune response in these patients who have exhausted all options. Intratumoral injections with tilsotolimod are designed to selectively enable the T-cells to recognize and attack cancers that remained elusive and unrecognized by the immune system exposed to checkpoint inhibitors alone, while limiting toxicity or impact on healthy cells in the body.

Idera Pharmaceuticals Enters into a Clinical Development Support Agreement with Pillar Partners Foundation

Idera Pharmaceuticals Inc. announced it has entered into a clinical development support agreement with Pillar Partners Foundation. Under the terms of the agreement Pillar Partners will provide direct funding to support three investigator initiated clinical trials to further strategically expand the clinical research of IMO-2125, Idera’s toll-like receptor (“TLR”) 9 agonist into broader melanoma populations and other solid tumors. For these trials, Idera will provide IMO-2125. Idera is currently enrolling a Phase 3 (“ILLUMINATE-301”) trial of intratumoral administration of IMO-2125 in combination with ipilimumab in patients with anti-PD-1 refractory metastatic melanoma. The three trials within the terms of this agreement are: A Phase 1/2 open label study of intratumoral IMO-2125 in combination with intratumoral ipilimumab and IV nivolumab in a protocol open to multiple tumor types including non-small cell lung cancer (“NSCLC”), melanoma, squamous cell carcinoma of the head and neck and urothelial carcinoma. The principal investigator initiating this trial is Aurélien Marabelle, MD, PhD, Clinical Director of the Cancer Immunotherapy Program at Institut Gustave Roussy, Villejuif, France. A Phase 2 study of intratumoral IMO-2125 in combination with IV pembrolizumab in patients with NSCLC. The principal investigator initiating this trial is Arafat Tfayli, MD, FRCP, Professor of Clinical Medicine, Director of Research, NK Basile Cancer Institute, American University of Beirut Medical Center, Beirut, Lebanon. A Phase 2 placebo controlled study of intradermal administration of IMO-2125 in patients with T3/T4 primary melanoma scheduled to undergo a combined re-excision and sentinel node biopsy procedure. The principal investigators initiating this trial are Bas Koster, MD, Fons van den Eertwegh MD, PhD, and Tanja de Gruijl, PhD, who is Professor of Translational Tumor Immunology and Co-Director of the Cancer Immunology Program at the VU University Medical Center, Cancer Center Amsterdam, The Netherlands.

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