Mark Halperin's Daybook

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At 8 p.m., Mitch McConnell will debate Democratic challenger Alison Lundergan Grimes in Lexington. This is the race's only debate. Spidey sense says that the Leader will come armed with a thing or two to try to discombobulate his less experienced rival. Watch the debate live here.

Hillary Clinton is in Las Vegas for a fundraiser with Harry Reid. The $1,000-per-person event ($10,000 each for VIPs) is scheduled for 8:00 p.m. She’s booked later this evening at an annual University of Nevada, Las Vegas fundraier. Starting at 10 p.m., Clinton will pose for photos at the Bellagio with guests at who dropped $20,000 on tickets, followed by a 10:30 p.m. speech and Q&A (open to press).

Mitt Romney will campaign for GOP Senate candidate Joni Ernst in Iowa, where the new Bloomberg Politics/Des Moines Register poll suggests he would beat Clinton in a hypothetical 2016 presidential match-up in the state. You can bet that those close to Romney bullish about his '16 prospects are going to keep touting this survey. The Ernst rally in Cedar Rapids starts at 10:30 a.m. 

President Obama is D.C. with no public events. Because it's Columbus Day, there will be no White House briefing.

At noon, Joe Biden will be at a private residence in Manalapan, Florida, for a Democratic National Committee event (closed to press). From there he’ll join Charlie Crist at 2:15 p.m. for a rally at Temple Beth Shira in Boca Raton, before the two make an appearance at Broward Community College in Coconut Creek at 4:15 p.m. (remarks only open to press). Around the same time, his wife, Dr. Jill Biden, will drop by a campaign phone bank at Florida Atlantic University with lieutenant governor candidate Annette Taddeo. At 6 p.m., she’s off to the American Legion Post 29 in Miami for a final Crist event, while the vice president finishes his day at a private residence in Parkland, Florida, for another closed-press 6:15 p.m. event for the gubernatorial candidate.

Jeb Bush has a series of stops in Michigan, starting at the Kent County Republican headquarters in Grand Rapids to stump for U.S. Senate candidate Terri Lynn Land at 10:30 a.m. From there, he goes to Lansing for a 2:20 p.m. visit to the Michigan Republican Party HQ and on to a 6:30 p.m. Governors’ Gala fundraiser with Gov. Rick Snyder in Troy. Tickets cost $500 to attend; $5,000 gets you a private table and photo.

Rick Perry will miss a scheduled court appearance today regarding his indictment. His absence was excused by a judge last month because of a pre-scheduled economic mission trip to Europe.

The CDC will hold a noon briefing on its investigation into how a health care worker became infected with Ebola in Texas.

John McCain is spending a full day campaigning with Louisiana GOP Senate candidate Bill Cassidy, starting with a 9:00 a.m. rally in Covington, Louisiana, before pushing on to events in Baton Rouge, Lafayette, and a final stop at 6:00 p.m. in Bossier City. Cassidy remains a less distinct figure to voters and the national media than other Republicans trying to unseat Democratic incumbents, like Tom Cotton, Thom Tillis, Scott Brown, etc.

Sarah Palin will deliver the keynote speech at Trinity Christian School in Williston, North Dakota. The fundraiser gets underway at 7:00 p.m.

More on the new Bloomberg Politics/Des Moines Register poll on "With All Due Respect" at 5:00 p.m.

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