New Bird Flu Strain Spreads in China as Third Person Dies

The new strain of bird flu that’s emerged in eastern China killed a third person, as the World Health Organization said drugs made by Roche Holding AG and GlaxoSmithKline Plc are effective against the deadly virus.

A 64-year-old man from Huzhou City was confirmed to be infected with the H7N9 strain of avian influenza and was admitted to a hospital on March 31, China’s official Xinhua News Agency reported today. The virus has infected at least 10 people and killed three of them since China’s health ministry reported the first cases last month, the wire service said.

Two contacts of one infected person in Shanghai developed symptoms and one died, though no laboratory confirmation is available of what illness was involved, the Geneva-based WHO said yesterday in a statement. There’s no evidence of human-to-human transmission of the virus, the agency said. The extent of the outbreak, the source of infection and the mode of transmission are being investigated, and it’s too early to tell whether the cases may signal a pandemic, according to the WHO.

“Until we know what the source of infection is, it’d be premature to say one way or the other,” Gregory Hartl, a WHO spokesman in Geneva, said by phone yesterday. “We wouldn’t be dealing with a full deck.”

Poultry Worker

Health authorities in Shanghai are investigating the death of a poultry worker, the city government said in a statement posted on its official microblog today. The city’s center for disease control and prevention is carrying out tests to see whether he was infected with the H7N9 virus, it said. About eight people had had close contacts with the man, who died yesterday at a city hospital, the Shanghai government said.

Data from China’s Ministry of Agriculture showed that a total of 25 H7N9 bird flu strains have been detected in wild birds around the world and that the virus hasn’t been found in poultry, according to Xinhua. China is on the flight path of migratory birds, the agency reported, citing the ministry.

The new virus is sensitive to Roche’s Tamiflu and Glaxo’s Relenza treatments, Hartl said.

“There was some initial doubt but those doubts seem to have been put aside after a lot of work done in our collaborating center in Beijing,” he said.

Drug Demand

Roche will provide an update on demand for Tamiflu when it reports quarterly sales, Daniel Grotzky, a spokesman for the Basel, Switzerland-based company, said in an e-mail. David Daley, a spokesman for London-based Glaxo, declined to comment on demand for Relenza.

Concerns that the spread of infections may prompt consumers to eat less poultry led soybeans to decline for a second day. Soybean meal is a primary ingredient in chicken feed. The contract for May delivery lost as much as 0.3 percent to $13.76 a bushel on the Chicago Board of Trade and was at $13.7675 by 3:22 p.m. Singapore time. Futures fell 1 percent yesterday.

Shanghai issued a level-3 flu alert on April 2, the second-lowest of four levels, following the deaths of the two men, ages 87 and 27, in China’s financial hub last month.

Investigations still haven’t uncovered how the two men contracted the virus, and tests have yet to prove whether it can be transmitted among humans, Wu Fan, head of the city’s disease control center, said at a briefing that day.

Dead Pigs

There’s also no evidence that the virus is related to dead pigs found in a Shanghai river last month, Wu said. More than 11,000 hog carcasses were pulled from the Huangpu river, which supplies about 22 percent of the city’s water, and thousands more were found in neighboring Zhejiang province.

The discovery of the new virus has prompted other cities in the region to intensify checks. Beijing, the Chinese capital, started monitoring for H7N9 influenza, Xinhua reported, while Taiwan’s Central News Agency said March 31 the island is on the alert for the bug. Officials in Hong Kong activated the alert response level, the lowest of three in the island’s pandemic preparedness plan, and advised people to avoid direct contact with birds.

China’s Center for Disease Control and Prevention advised people against slaughtering poultry for ancestral worship as part of the Tomb-Sweeping holiday that starts today, Xinhua reported yesterday.

The new strain of H7N9 hasn’t previously appeared in humans, the WHO said. The virus’s genetic sequence shows it’s a combination of an H7N9 virus that circulates in birds and an H9N2 pathogen, the European Centre for Disease Prevention and Control said in a report yesterday.

Past Pandemics

The flu pandemics of the past century, including the 1918 Spanish flu that killed as many as 50 million people, have all been triggered by the mixing of human and animal flu viruses to create new pathogens to which people have no pre-existing immunity.

More than 600 people have been infected with the H5N1 bird flu strain since 2003, and almost 60 percent have died, according to the WHO. Most had direct contact with infected poultry, and the virus hasn’t acquired the ability to spread easily between people.

The H1N1 virus responsible for the 2009 swine flu pandemic originated in pigs, then mixed with human and avian viruses, touching off the first global influenza outbreak in more than 40 years and killing about 284,500 people, according to the U.S. Centers for Disease Control and Prevention.

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