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Modified Smallpox Vaccine Stymies Liver Cancer in Study

A genetically modified smallpox vaccine shrunk tumors in liver cancer patients and extended survival more than a year, a study found.

The therapy from closely held Jennerex Inc., called JX-594, or Pexa-Vec, is being tested in people with advanced hepatocellular carcinoma. The 16 patients who received a high dose of the medicine lived a median 14.1 months after injection, compared with 6.7 months for 14 patients on a low dose, according to the study published today by the journal Nature Medicine.