The grounds at Meadowood Napa Valley resort and spa in St. Helena, Calif.

The New Way to Spend a Three-Day Weekend in Napa

America’s most famous wine region feels fresh again, thanks to pioneering hoteliers, distillers, and chefs.

DAY 1

A room at the Meadowood Spa.
Photographer: Jake Stangel for Bloomberg Pursuits

Check in to Las Alcobas, the first luxury hotel to open in the Napa area in almost a decade. Its 68 rooms (from $695) have private terraces with fireplaces and views of Beringer Vineyards. Grab lunch at the main restaurant, Acacia House, where San Francisco culinary darling Chris Cosentino makes a dynamite pork belly BLT.

Two miles down Silverado Trail is Meadowood Napa Valley, home of the namesake three-star restaurant; new this fall is an eight-suite spa with a 104F mineral soaking pool and massages (rooms from $550).

Afterward, catch a show at the Blue Note Napa jazz club. Housed in the former opera house downtown, it opens in September.

DAY 2

The Napa Valley Vine Trail bike path.
Photographer: Jake Stangel for Bloomberg Pursuits

Give your chauffeur a break and hit the expanded Napa Valley Vine Trail, a set of bike paths that connect 47 miles of scenic byways from Vallejo to Calistoga. Stop at Domaine Carneros, which serves flights of Champagne paired with Tsar Nicoulai caviar (from $120). Later, drop by Kapcsándy Family Winery (tastings from $150; 707-948-3100), a by-appointment-only spot beloved by insiders; the vineyard made its name supplying grapes for Beringer.

For dinner at Two Birds One Stone, the newly opened yakitori spot by chefs Sang Yoon and Douglas Keane, try the deviled Jidori eggs, harvested from a breed of chicken often compared to Kobe beef, and the pork belly with spicy yuzu glaze.

DAY 3

Single Thread Farms.
Photographer: Eric Wolfinger

Oxbow Public Market is a favorite among locals and visitors; vendors at the covered stalls include oyster shuckers, chocolate makers, and produce sellers. For breakfast, order a bacon-and-egg tartine on warm pain au levain at the Model Bakery as fortification before souvenir hunting—pick up 100-year-old balsamic vinegar at Napastäk or a vintage edition of The Art of Cooking at Napa Bookmine.

Once you’re fully stocked, head to Napa Valley Distillery (tastings from $15), one of the first small-batch producers to set up shop after a state law passed last October made it legal to sell distilled spirits. If you book in advance, you can sample Napa’s own spin on limoncello—a combination of vodka made from sauvignon blanc grapes and liqueur created with Meyer lemons.

Cap your stay at Single Thread Farms (from $700), a 5-acre plot in Healdsburg where the owners work homegrown ingredients like asatsuki onions into their 11-course tasting menus. If a meal there makes you want to stay a little longer, above the restaurant are five sumptuous rooms, all with exposed beams and whitewashed brick walls.