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Kathy Callender, 67
Golden, Colo.

After 12 years in business, PharmaJet may finally be able to sell its first product: a simple, needle-free injection device with a disposable syringe designed for use in third-world countries that can help prevent injury and the spread of disease. The company just received clearance from the Food & Drug Administration to use the tool for vaccines and injectable medicines. The 25-person company has not recorded any revenues to date, but plans to start selling its devices this year. So far, it has been developing the product with help from angel investors. "I want to make a difference in global world health," says Callender, a 35-year veteran of the health-care industry. "Before starting the firm, my husband and I would do medical mission work in the developing world, and it really just showed us how much need there is out there. I want to get needles out of the garbage and prevent injury to workers and patients."