Last $1.11 USD
Change Today -0.0099 / -0.88%
Volume 229.8K
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As of 10:22 AM 03/2/15 All times are local (Market data is delayed by at least 15 minutes).
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Company Description

Contact Info

7707 Gateway Boulevard

Suite 140

Newark, CA 94560

United States

Phone: 510-456-4000

Fax: 510-456-4001

StemCells, Inc. is engaged in the research, development, and commercialization of stem cell therapeutics and related tools and technologies for academia and industry. The company’s primary research and development efforts are focused on identifying and developing stem and progenitor cells as potential therapeutic agents. Its major product development program is its Central Nervous System (CNS) Program, in which the company is developing applications for HuCNS-SC cells, its proprietary human neural platform technology. The company is in clinical development with its HuCNS-SC cells for a range of diseases and disorders of the CNS. Therapeutic Product Development Programs CNS Program The company’s platform technology, HuCNS-SC cells, is an expanded composition of normal human neural stem cells. Its CNS Program is initially focusing on developing clinical applications in which transplanting HuCNS-SC cells would protect or restore organ function of the patient before such function is irreversibly damaged or lost due to disease progression. Its initial target indications are Pelizeaus-Merzbacher Disease (PMD) and diseases in which deficient myelination plays a central role, such as cerebral palsy or multiple sclerosis; spinal cord injury; Alzheimer’s disease; and disorders in which retinal degeneration plays a central role, such as age-related macular degeneration or retinitis pigmentosa. The company completed a Phase I clinical trial in PMD. In its preclinical research, the company has shown that HuCNS-SC cells differentiate into oligodendrocytes, the myelin producing cells, and produce myelin. The company has transplanted HuCNS-SC cells into the brain of the mutant shiverer mouse, which is deficient in myelin, and shown widespread engraftment of human cells that matured into oligodendrocytes, and that the human oligodendrocytes myelinated the mouse axons. The company completed a six-patient Phase I clinical trial of its HuCNS-SC cells in infantile and late infantile neuronal ceroid lipofuscinosis (NCL), which is a neurodegenerative disorder of the brain. Its preclinical data demonstrate that HuCNS-SC cells, when transplanted in a mouse model of infantile NCL, engraft, migrate throughout the brain, produce the relevant missing enzyme, measurably reduce the toxic storage material in the brain, protect host neurons so that more of them survive, and delay the loss of motor function compared to a control group of non-transplanted mice. The company is conducting a Phase I/II clinical trial to evaluate its HuCNS-SC cells as a treatment for chronic spinal cord injury. The trial is being conducted in Switzerland, Canada, and the United States. The company initiated a Phase I/II clinical trial in dry age-related macular degeneration, the more common form of age-related macular degeneration. The company is also conducting preclinical studies of its HuCNS-SC cells in Alzheimer’s disease. Other CNS Collaborations The company has collaborated on various research programs to assess both the in vitro potential of the HuCNS-SC cells and the effects of transplanting HuCNS-SC cells into various preclinical animal models. One such collaboration is with researchers at the Stanford University School of Medicine that evaluated the company’s human neural stem cells in animal models of stroke. Tools and Technologies Programs In the company’s tools and technologies programs, it is engaged in developing and commercializing applications of its technologies to enable stem cell-based research. The company markets a range of proprietary cell culture products, research grade human cells, and antibody reagents under the SC Proven brand. Its cell culture products include iSTEM, GS1-R, GS2-M, RHB-A, RHB-Basal, NDiff227, NDiff N2, and NDiff N27 supplements. Its cell lines available for research use include human neural stem cells and hFB101, ultra primary human fibroblasts for genetic reprogramming. The company’s antibody reagents include STEM24, STEM101, STEM121, and STEM123, which could be used for cell detection, isolation, and characterization. The company also markets various human cell lines for use in research, includi

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