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Last $78.04 USD
Change Today +0.81 / 1.05%
Volume 161.5K
CRL On Other Exchanges
New York
As of 5:15 PM 11/27/15 All times are local (Market data is delayed by at least 15 minutes).
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Company Description

Contact Info

251 Ballardvale Street

Wilmington, MA 01887

United States

Phone: 781-222-6000

Fax: 978-988-5665

Charles River Laboratories International, Inc., an early-stage contract research company, provides drug discovery and preclinical development services worldwide. Segments The company operates through three segments: Research Models and Services (RMS), Discovery and Safety Assessment (DSA), and Manufacturing Support (Manufacturing). RMS segment This segment supplies research models to the drug development industry. This segment includes Research Models and Research Model Services. Research Models The company’s Research Models business includes the production and sale of research models. Research Models: A portion of this business includes the commercial production and sale of research models, principally purpose-bred rats and mice for use by researchers. The company provides its rodent models to various clients worldwide, including various pharmaceutical companies, a range of biotechnology companies and various government agencies, major hospitals and academic institutions. The company’s research models include standard stocks and strains and disease models, such as those with compromised immune systems, which are in demand as early-stage research tools. The company’s research models include outbred, which are purposefully bred for heterogeneity; inbred, which are bred to be genetically identical; spontaneous mutant, which contain a naturally occurring genetic mutation (such as immune deficiency); hybrid, which are the offspring of two different inbred parents; and other genetically modified research models, including knock-out models with one or more disabled genes and transgenic models. Certain of the company’s research models are proprietary, disease-specific mouse and rat models used to find new treatments for diseases, such as diabetes, obesity, cardiovascular, and kidney disease. The company is focusing its disease model program on five areas of research, such as oncology, central nervous system, metabolic, cardiovascular, and renal diseases. The company is also a premier provider of purpose bred, specific-pathogen-free (SPF) large research models to the biomedical research community. Research Model Services RMS also offers various services designed to support its clients' use of research models in screening drug candidates. These services capitalize on the technologies and relationships developed through the company’s research model business, and address the need among pharmaceutical and biotechnology companies to outsource the non-core aspects of their drug discovery activities. These services include those which are related to the maintenance and monitoring of research models, and managing research operations for government entities, academic organizations and commercial clients. The company has three service offerings in research models services, such as Genetically Engineered Models and Services, Insourcing Solutions, and Research Animal Diagnostic Services. Genetically Engineered Models and Services: The company breeds and maintains research models purchased or purposefully created by its clients for biomedical research activities. The creation of a genetically engineered model is a critical scientific event, but it is only the first step in the discovery process. The company also provides breeding expertise and colony development, quarantine, health and genetic monitoring, germplasm cryopreservation, and rederivation, including assisted reproduction. The company provides these services to clients worldwide from pharmaceutical and biotechnology companies to hospitals and universities. Insourcing Solutions: The company manages research operations (including recruitment, training, staffing and management services) for government entities, academic organizations, and commercial clients. Research Animal Diagnostic Services: The company monitors and analyzes the health profiles of the research models and cell lines of its clients. The company is able to serve as its clients' sole-source testing laboratory, or as an alternative source supporting its clients’ internal laboratory capabilities. The company also offers non-Good Laboratory Practice (GLP) biomarker assay platforms


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