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Last $79.61 USD
Change Today +0.60 / 0.76%
Volume 303.7K
CRL On Other Exchanges
New York
As of 8:04 PM 03/27/15 All times are local (Market data is delayed by at least 15 minutes).
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Company Description

Contact Info

251 Ballardvale Street

Wilmington, MA 01887

United States

Phone: 781-222-6000

Fax: 978-988-5665

Charles River Laboratories International, Inc., together with its subsidiaries, is a provider of solutions that accelerate the drug discovery and development process, including research models and associated services and outsourced preclinical services. Segments The company has two segments, Research Models and Services (RMS) and Preclinical Services (PCS). Research Models and Services segment The RMS segment supplies research models to the drug development industry. This segment comprises Research Models, Research Model Services, and Endotoxin and Microbial Detection. Research Models The company’s Research Models business comprises the production and sale of research models and avian vaccine services. A significant portion of this business comprises the commercial production and sale of research models, principally purpose-bred rats and mice for use by researchers. The company provides its rodent models to various clients worldwide, including most pharmaceutical companies, a range of biotechnology companies, government agencies, and hospitals and academic institutions. The company’s research models include both standard strains and disease models, such as those with compromised immune systems, which are in demand as early-stage research tools. The company’s research models include the following: outbred, which are purposefully bred for heterogeneity; inbred, which are bred to be genetically identical; spontaneous mutant, which contain a naturally occurring genetic mutation (such as immune deficiency); hybrid, which are the offspring of two different inbred parents; and other genetically modified research models, including knock-out models with one or more disabled genes and transgenic models. Certain of its research models are proprietary, disease-specific mouse and rat models used to find new treatments for diseases, such as diabetes, obesity, cardiovascular and kidney disease. The company focuses its disease model program on five areas of research: oncology, central nervous system, metabolic, cardiovascular and renal diseases. The company is also a premier provider of purpose bred, specific-pathogen-free (SPF) large research models to the biomedical research community. Avian Vaccine Services: The company supplies SPF fertile chicken eggs and chickens. SPF chicken embryos are used by animal health companies as self-contained ‘bioreactors’ for the manufacture of live viruses. These viruses are used as a raw material primarily in poultry, as well as human and veterinary vaccine applications. The production of SPF eggs is performed under biosecure conditions, similar in many ways to its research model production. The company also operates a specialized avian laboratory in the United States, which provides in-house quality control testing of the SPF flocks, offers testing services to vaccine companies and commercial poultry operations, and manufactures poultry diagnostics and bulk antigens for poultry vaccines. Research Model Services: The company also offers various services designed to support its clients' use of research models in screening drug candidates. These services capitalize on the technologies and relationships developed through its research model business, and address the need among pharmaceutical and biotechnology companies to outsource the non-core aspects of their drug discovery activities. These services include those which are related to the maintenance and monitoring of research models, and those which are designed to implement efficacy screening protocols to improve the client's drug evaluation process. The company offers four major categories of research models services-Genetically Engineered Models and Services, Insourcing Solutions, Discovery Research Services and Research Animal Diagnostic Services. Genetically Engineered Models and Services (GEMS): The company breeds and maintains research models purchased or purposefully created by its clients for biomedical research activities. The creation of a genetically engineered model (GEM) is a critical scientific event, but it is only the first step in the discovery process. The company also provides breeding expertise and


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