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Last $9.53 USD
Change Today +0.18 / 1.93%
Volume 2.3M
ZIOP On Other Exchanges
As of 8:10 PM 05/6/15 All times are local (Market data is delayed by at least 15 minutes).

ziopharm oncology inc (ZIOP) Snapshot

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03/20/15 - $14.40
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ziopharm oncology inc (ZIOP) Details

ZIOPHARM Oncology, Inc., a biotechnology company, employs gene expression, control, and cell technologies to deliver cell-based therapies for the treatment of cancer. Its synthetic immuno-oncology programs, in collaboration with Intrexon Corporation and the MD Anderson Cancer Center, comprise chimeric antigen receptor T cell (CAR-T) and other adoptive cell based approaches that use both non-viral and viral gene transfer methods for broad scalability. The company is also developing programs in various stages of development together with Intrexon Corporation's RheoSwitch Therapeutic System(r) technology, a switch to turn on and off, and precisely modulate, gene expression in order to improve therapeutic index. Its pipeline includes various gene and cell-based therapeutics in both clinical and pre clinical testing which are focused on hematologic and solid tumor malignancies. ZIOPHARM Oncology, Inc. was founded in 2003 and is headquartered in Boston, Massachusetts.

27 Employees
Last Reported Date: 02/26/15
Founded in 2003

ziopharm oncology inc (ZIOP) Top Compensated Officers

Chief Executive Officer and Director
Total Annual Compensation: $700.0K
Chief Financial Officer, Chief Accounting Off...
Total Annual Compensation: $238.7K
Chief Legal Officer, Executive Vice President...
Total Annual Compensation: $472.5K
Compensation as of Fiscal Year 2014.

ziopharm oncology inc (ZIOP) Key Developments

ZIOPHARM Oncology, Inc. Announces Initiation of Phase 1 Study of Ad-RTS-IL-12 Gene Therapy in Patients with Brain Cancer

ZIOPHARM Oncology, Inc. announced the initiation of a Phase 1 study of Ad-RTS-hIL-12 + veledimex in patients with recurrent or progressive glioblastoma or Grade III malignant glioma, a form of brain cancer. Ad-RTS-hIL-12 is a novel gene therapy candidate for the controlled expression of IL-12, a critical protein for stimulating an anti-cancer T cell immune response. The Phase 1 study is designed to examine a gene therapy treatment strategy for high grade gliomas with the goal of generating an anti tumor T cell immune response. Eligible patients will be stratified to one of two groups, according to clinical indication for tumor resection. One group will undergo resection plus injection and the other group will undergo stereotactic injection. Ad-RTS-hIL-12 will be injected locally in the tumor lesion, with IL-12 expression levels tightly regulated by escalating doses of the oral activator ligand veledimex. This strategy makes it feasible to control the gene therapy in vivo and to lower or terminate IL-12 expression in the event of severe or unexpected toxicities. The primary objective of the study is to determine the safety and tolerability of a single intra tumoral Ad-RTS-hIL-12 injection plus escalating oral veledimex doses. Secondary Objectives are to determine the veledimex maximum tolerated dose, the immune responses elicited by Ad-RTS-hIL-12 and veledimex, and investigator assessment of response, including the tumor objective response rate and progression-free survival, and determine overall survival, among other measures. The study is expected to enroll up to 72 subjects at up to 12 leading treatment centers. Among the centers expected to begin enrollment are the Stanford School of Medicine, Dana Farber/Brigham and Women's, the University of Chicago Pritzker School of Medicine, Cedars-Sinai/the David Geffen School of Medicine at the University of California, Los Angeles, and Northwestern Memorial Hospital.

ZIOPHARM Oncology, Inc. Announces Initiation of Phase 1b/2 Study of Ad-RTS-hIL-12 + veledimex

ZIOPHARM Oncology, Inc. announced the initiation of a Phase 1b/2 study of Ad-RTS-hIL-12 + veledimex following standard chemotherapy for the treatment of patients with locally advanced or metastatic breast cancer. The study will be conducted at the Memorial Sloan Kettering Cancer Center in New York led by principal investigator Heather L. McArthur, M.D., M.P.H., Assistant Attending Physician, Breast Medicine Service, Memorial Sloan Kettering Cancer Center. Ad-RTS-hIL-12 is a novel gene therapy candidate for the controlled expression of IL-12, an important protein for collapsing tumor stroma and stimulating an anti-cancer T cell immune response. The study is designed to examine the safety, tolerability and efficacy of Ad-RTS-hIL-12 immunotherapy in women with locally advanced or metastatic breast cancer of all subtypes. Up to 40 subjects may be enrolled in the study, including up to 20% (8 subjects) with HER2+ breast cancer. Subjects who are receiving first- or second-line standard therapy and have achieved a partial response or stable disease are eligible. Following entry into the trial, patients will go on a treatment holiday from chemotherapy and enter an immunotherapy phase of treatment. A single cycle of Ad-RTS-hIL-12, along with the oral activator ligand veledimex, will be given during the immunotherapy phase, with the goal of maintaining or improving pre-study response. Continuation of HER2-targeted antibody therapy is permitted during this immunotherapy phase for women with HER2+ disease. The primary study objective is to evaluate the safety and tolerability of Ad-RTS-hIL-12 immunotherapy. Secondary objectives include overall response rate, disease control rate and impact of treatment on tumor and serum immune biomarkers.

ZIOPHARM Oncology, Inc. and Intrexon Corporation Enters into Worldwide License and Collaboration Agreement with ARES Trading S.A

On March 27, 2015, ZIOPHARM Oncology, Inc. and Intrexon Corporation entered into a worldwide License and Collaboration Agreement or the Ares Trading Agreement with ARES Trading S.A. through which the parties established a collaboration for the research and development and commercialization of Products for the prophylactic, therapeutic, palliative or diagnostic use for cancer in humans. The Ares Trading Agreement provides for the establishment of committees composed of Ares Trading and Intrexon representatives that will govern activities in, among others, the areas of project establishment, research plans and intellectual property. The Ares Trading Agreement grants Ares Trading an exclusive, worldwide, royalty-bearing, sub-licensable license under the company's and Intrexon's patents, know-how and proprietary platform of research tools and technology necessary for the company and Intrexon to perform their tasks directed towards the design, identification, culturing, and/or production of genetically modified cells to generate and test Chimeric Antigen Receptor T-Cell Products solely for the development, regulatory approval and commercialization of Products containing such Chimeric Antigen Receptor T-Cell Products pursuant to the licenses granted in clauses (b) and (c) of this paragraph; develop and commercialize Products in the Field, worldwide, provided that such Products are not Out-of-Scope Products where Ares Trading has not exercised its Option; and commercialize the chimeric antigen receptor for Products. Ares Trading will pay an upfront fee of $115.0 million to Intrexon as consideration for entry into the Ares Trading Agreement. Intrexon will pay 50% of the fee to the company in accordance with the ECP Amendment. Ares Trading will, pursuant to the terms of the Ares Trading Agreement, pay Intrexon certain fees for the research and development activities related to the products.


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