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Last $1.17 USD
Change Today +0.02 / 1.74%
Volume 924.8K
PPHM On Other Exchanges
As of 2:32 PM 09/1/15 All times are local (Market data is delayed by at least 15 minutes).

peregrine pharmaceuticals (PPHM) Snapshot

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Day High
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52 Week High
10/15/14 - $1.75
52 Week Low
08/10/15 - $1.00
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Average Volume 10 Days
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peregrine pharmaceuticals (PPHM) Related Businessweek News

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peregrine pharmaceuticals (PPHM) Details

Peregrine Pharmaceuticals, Inc., a biopharmaceutical company, researches and develops monoclonal antibodies for the treatment and diagnosis of cancer in the United States and internationally. The company’s lead immunotherapy candidate, bavituximab, which is in Phase III development stage for the treatment of previously-treated non-small cell lung cancer along with various investigator-sponsored trials evaluating other treatment combinations and additional oncology indications. It is also involved in the development of molecular imaging agent, 124I-PGN650, which is in exploratory clinical trial for the imaging of various solid tumor types. The company provides current good manufacturing practice services from cell line development to commercial biomanufacturing for its third-party customers. It has license agreements with the University of Texas Southwestern Medical Center at Dallas; Genentech, Inc.; Avanir Pharmaceuticals, Inc.; Lonza Biologics; Affitech A/S; and Merck KGaA.; and collaboration agreement with AstraZeneca PLC for immuno-oncology combination clinical trial. Peregrine Pharmaceuticals, Inc. was founded in 1981 and is headquartered in Tustin, California.

211 Employees
Last Reported Date: 07/14/15
Founded in 1981

peregrine pharmaceuticals (PPHM) Top Compensated Officers

Chief Executive Officer, President, Director,...
Total Annual Compensation: $517.2K
Chief Financial Officer
Total Annual Compensation: $388.0K
Vice President, General Counsel and Corporate...
Total Annual Compensation: $346.7K
Head of Clinical & Regulatory Affairs and Vic...
Total Annual Compensation: $298.9K
Vice President of Intellectual Property
Total Annual Compensation: $319.9K
Compensation as of Fiscal Year 2015.

peregrine pharmaceuticals (PPHM) Key Developments

AstraZeneca and Peregrine Pharmaceuticals to Collaborate on Solid Tumor Trial

AstraZeneca and Peregrine Pharmaceuticals are collaborating on an early-phase clinical trial to evaluate the safety and efficacy of two novel investigational drugs in patients with a range of solid tumor types. The Phase 1/1b trial, slated to start in 2016, will combine it's durvalumab, an anti-PDL1 immune checkpoint inhibitor, with Peregrine's bavituximab, a phosphatidylserine-signaling pathway inhibitor. Preclinical data show that tumor-specific T-cells have a prolonged ability to continue attacking a tumor when the antitumor activity of bavituximab is combined with checkpoint inhibitors such as PDL1 antibodies, the companies say. The nonexclusive collaboration is the latest indication of significant interest in Peregrine's bavituximab as a potential key component in immuno-oncology combos, says company spokesman Tim Brons.

Peregrine Pharmaceuticals, Inc. Proposes Amendment to Certificate of Incorporation

Peregrine Pharmaceuticals, Inc. announced that an annual meeting of stockholders will be held on October 15, 2015, to approve an amendment to certificate of incorporation, as amended, to increase the number of shares of common stock authorized for issuance thereunder from 325 million to 500 million shares.

Peregrine Pharmaceuticals, Inc Presents Data at Annual Immunotherapy and Vaccine Summit Supporting Ability of Bavituximab to Mediate Anti-Tumor T Cell Responses Across Multiple Tumor Types

Peregrine Pharmaceuticals, Inc. announced the presentation of a range of clinical, translational and pre-clinical study results of bavituximab, Peregrine’s investigational phosphatidylserine (PS)-signaling pathway inhibitor, to promote anti-tumor T cell mediated activity in several tumor types. Bavituximab is an investigational immunotherapy designed to assist the body's immune system by targeting and modulating the activity of phosphatidylserine (PS), a highly immune-suppressive signaling molecule expressed broadly on the surface of cells in the tumor microenvironment. Peregrine’s PS signaling pathway inhibitor candidates, including bavituximab, reverse the immunosuppressive environment that many tumors establish in order to proliferate and fight cancer by activating macrophages and cytotoxic T cells in tumors. Preclinical data demonstrate that combining the enhanced T cell anti-tumor activity of bavituximab-like antibodies with checkpoint inhibitors, such as anti-PD-1 antibodies, results in significantly improved tumor control in multiple models of cancer. The potential of bavituximab to shift the tumor microenvironment from immuno-suppressive in which tumors evade immune detection to a state of immune activation in which the immune system recognizes and fights the tumor. Presented findings demonstrate that bavituximab-like antibodies significantly increase the prevalence of tumor infiltrating CD8+ T-cells and immune-activating cytokines, while decreasing macrophages and myeloid cells that allow the tumor to evade immune detection. This elucidation and confirmation of bavituximab’s mechanism of action highlights the potential of bavituximab to enhance the anti-tumor effects of both chemotherapy and immune checkpoint inhibitors. Bavituximab increases the number of activated CD8+ cells in the tumor, which stimulates PD-1 expression, thereby upregulating the target for checkpoint inhibitors such as anti-PD-1 and anti-PD-L1. Results from several clinical and preclinical studies in a range of tumor types show that bavituximab and bavituximab-like antibodies, in combination with conventional therapy, have consistently demonstrated estimated survival curves that plateau.


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Valuation PPHM Industry Range
Price/Earnings NM Not Meaningful
Price/Sales 8.1x
Price/Book 3.8x
Price/Cash Flow NM Not Meaningful
TEV/Sales 6.1x

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