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Last $4.43 USD
Change Today -0.34 / -7.13%
Volume 597.4K
OHRP On Other Exchanges
As of 5:10 PM 11/27/15 All times are local (Market data is delayed by at least 15 minutes).

ohr pharmaceutical inc (OHRP) Snapshot

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ohr pharmaceutical inc (OHRP) Details

OHR Pharmaceutical, Inc., a pharmaceutical company, focuses on the development of novel therapeutics and delivery technologies for the treatment of ocular disease. Its lead clinical program is OHR-102 eye drops, a novel therapeutic product, which could provide a non-invasive therapy to improve vision outcomes. The company is evaluating OHR-102 eye drops in various Phase II studies for the treatment of retinal diseases, including wet-AMD, retinal vein occlusion, proliferative diabetic retinopathy, and diabetic macular edema. Its preclinical pipeline of sustained release programs include sustained release formulations of small molecule and protein therapeutics for the treatment of ocular diseases, such as steroid induced glaucoma, allergies, and retinal disease. The company is headquartered in New York, New York.

13 Employees
Last Reported Date: 12/22/14

ohr pharmaceutical inc (OHRP) Top Compensated Officers

Founder, President, Chief Technology Officer ...
Total Annual Compensation: $219.0K
Chief Financial Officer and Vice President of...
Total Annual Compensation: $177.7K
Compensation as of Fiscal Year 2014.

ohr pharmaceutical inc (OHRP) Key Developments

Ohr Pharmaceutical Presents New Data From OHR-102 Phase II IMPACT Study in Wet-AMD

Ohr Pharmaceutical, Inc. presented additional positive data from the Phase 2 IMPACT study evaluating OHR-102 (Squalamine lactate ophthalmic solution, 0.2%) combination therapy for the treatment of the wet form of age-related macular degeneration (wet-AMD). The data were presented by Dr. David S. Boyer, retina specialist at Retina-Vitreous Associates Medical Group and investigator in the study, at the annual meeting of the American Academy of Ophthalmology (AAO), in Las Vegas. New data from the IMPACT study demonstrates that visual acuity outcomes correlate with the size and composition of lesions in the study patients. Previously, a positive benefit in terms of visual acuity outcomes was shown in patients with classic containing lesions. Detailed analyses of lesion characteristics and their predictive effect on visual acuity outcomes demonstrated that the smaller the occult CNV size, the more pronounced the combination treatment effect on visual acuity, whether or not there was a classic component present. This size effect was not observed in those patients treated with Lucentis® (anti-VEGF) monotherapy. The size of occult CNV, irrespective of a classic CNV component, was most important in predicting treatment success with the combination of OHR-102 plus Lucentis. In those patients with occult CNV less than 10mm2 in area (n=94 of 128 completing the study), 40% of those treated with the combination of OHR-102 plus Lucentis achieved a gain of 3 or more lines of vision, compared with 26% of patients in the Lucentis monotherapy arm, a 54% additional benefit. In addition, mean gains in visual acuity compared to baseline were +11.0 letters for the OHR-102 plus Lucentis combination arm and +5.7 letters with Lucentis monotherapy, a clinically meaningful benefit of +5.3 letters. Importantly, this group of patients represents a larger proportion of the subjects enrolled in the IMPACT study than the classic containing group. The comprehensive Phase 3 clinical program will be comprised of double-masked, placebo-controlled, multicenter, international studies of OHR-102 administered twice a day in patients with newly diagnosed wet AMD, in combination with Lucentis injections. The primary endpoint will be a measurement of visual acuity gains at nine months, with patients followed to two years for safety. The eligibility criteria will include patients with choroidal neovascularization (CNV) secondary to AMD. The lesions in these patients may contain classic and/or occult CNV. The occult CNV component of these lesions must measure less than 10mm2 as assessed on fluorescein angiography.

Ohr Pharmaceutical Announces Submission of Special Protocol Assessment and Upcoming Presentation on OHR-102 at American Academy of Ophthalmology

Ohr Pharmaceutical, Inc. announced the company has submitted a Special Protocol Assessment (SPA) request to the U.S. Food and Drug Administration (FDA or agency), as part of the ongoing interaction with the FDA on the detailed design of the Phase 3 clinical development program of OHR-102 (Squalamine Lactate Ophthalmic Solution, 0.2%) for the treatment of neovascular Age-Related Macular Degeneration (wet AMD). The SPA request includes a detailed protocol that was designed based on previous guidance the company received from the agency, to address and adequately provide the agency with a Phase 3 program that produces data that would allow assessment of efficacy and safety of OHR-102 for the treatment of patients with wet AMD. The FDA may take up to 45 calendar days to provide comments to Ohr Pharmaceutical. The planned Phase 3 clinical trials are designed as well-controlled, double-masked, placebo-controlled, multicenter, international studies of OHR-102 administered twice a day in patients with newly diagnosed wet AMD, in combination with Lucentis® injections. The company expects to initiate the Phase 3 program in late 2015 and enroll the first patients by year-end 2015 or in the first calendar quarter of 2016.

Ohr Pharmaceutical, Inc. Reports Earnings Results for the Third Quarter and Nine Months Ended June 30, 2015

Ohr Pharmaceutical, Inc. reported earnings results for the third quarter and nine months ended June 30, 2015. The company recognized a net loss of approximately 3.3 million compared to a net loss of approximately 2.0 million for the same period in 2014. The company recognized a net loss of approximately 11.3 million, compared to a net loss of approximately 6.0 million for the same period in 2014.


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