Last $20.51 USD
Change Today +0.69 / 3.48%
Volume 45.7K
As of 8:10 PM 01/29/15 All times are local (Market data is delayed by at least 15 minutes).

intra-cellular therapies inc (ITCI) Snapshot

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intra-cellular therapies inc (ITCI) Details

Intra-Cellular Therapies, Inc., a biopharmaceutical company, develops novel drugs for the treatment of neuropsychiatric and neurologic diseases, and other disorders of the central nervous system (CNS). Its lead product candidate, ITI-007, which is in clinical development for the treatment of exacerbated and residual schizophrenia; bipolar disorders; sleep deficits associated with neurologic and psychiatric disorders; behavioral disturbances associated with dementia, including Alzheimer’s disease; sleep maintenance insomnia; major depressive disorders; and autism spectrum disorders, posttraumatic stress disorder, and intermittent explosive disorder. The company also develops ITI-002 phosphodiesterase (PDE) 1 inhibitors, including ITI-214 program that is in Phase-I clinical trial for the treatment of cognitive dysfunction in schizophrenia, Parkinson’s disease, cognitive impairment in Alzheimer’s disease, and attention deficit/hyperactivity disorders; as well as for cardiovascular and other diseases. In addition, it develops early stage drug development programs comprising ITI-012 casein kinase 1 inhibitors and ITI-009 gamma secretase activating protein inhibitors for Alzheimer’s disease. Further, the company develops PDE2 and PDE9 targets for treating neurodegeneration and bioenergetic failure in various CNS diseases. It has a license and collaboration agreement with Takeda Pharmaceutical Company Limited to research, develop, and commercialize the company’s proprietary compound ITI-214 and other selected compounds that selectively inhibit PDE1 for use in the prevention and treatment of human diseases. The company is headquartered in New York, New York.

intra-cellular therapies inc (ITCI) Top Compensated Officers

Co-Founder, Chairman, Chief Executive Officer...
Total Annual Compensation: $1.1M
Co-founder and Vice President of Business Dev...
Total Annual Compensation: $283.7K
Chief Financial Officer, Principal Accounting...
Total Annual Compensation: $357.5K
Compensation as of Fiscal Year 2013.

intra-cellular therapies inc (ITCI) Key Developments

Intra-Cellular Therapies, Inc. Presents at 33rd Annual J.P. Morgan Healthcare Conference, Jan-14-2015 02:00 PM

Intra-Cellular Therapies, Inc. Presents at 33rd Annual J.P. Morgan Healthcare Conference, Jan-14-2015 02:00 PM. Venue: Westin St. Francis Hotel, San Francisco, California, United States. Speakers: Sharon Mates, Co-Founder, Chairman, Chief Executive Officer and President.

Intra-Cellular Therapies, Inc. Presents at 7th Annual 2014 Deutsche Bank BioFEST, Dec-01-2014

Intra-Cellular Therapies, Inc. Presents at 7th Annual 2014 Deutsche Bank BioFEST, Dec-01-2014 . Venue: Four Seasons Hotel Boston, 200 Boylston Street, Boston, MA 02116, United States. Speakers: Sharon Mates, Co-Founder, Chairman, Chief Executive Officer and President.

Intra-Cellular Therapies, Inc. Announces Enrollment of First Patient in Phase 3 Trial of ITI-007 for the Treatment of Schizophrenia

Intra-Cellular Therapies, Inc. announced that the first patient has been enrolled in the ITI-007-301 Phase 3 trial, a randomized, double-blind, placebo-controlled trial designed to demonstrate the efficacy of ITI-007 for the treatment of schizophrenia. The company anticipates top-line results from this trial could be available as early as the fourth quarter of 2015. The company expects to initiate a second ITI-007 Phase 3 trial in schizophrenia, designated as the ITI-007-302 trial, in the first half of 2015. In December 2013, the company announced positive results from a Phase 2 trial in which ITI-007 exhibited antipsychotic efficacy with a favorable safety profile in patients with schizophrenia. About the ITI-007-301 Phase 3 Trial: The ITI-007-301 clinical trial is a randomized, double-blind, placebo-controlled Phase 3 trial designed to determine the safety and efficacy of ITI-007 for the treatment of schizophrenia. Over 400 patients with an acutely exacerbated episode of schizophrenia are planned to be randomized to receive one of three treatments: 60 mg ITI-007, 40 mg ITI-007, or placebo in a 1:1:1 ratio. Patients will receive study treatment orally once daily in the morning for 28 days. The primary endpoint for this clinical trial is change from baseline to Day 28 on the Positive and Negative Syndrome Scale (PANSS) total score. The PANSS is a well-validated 30-item rating scale that measures the ability of a drug to reduce schizophrenia symptom severity (Kay et al., 1987, Schizophrenia Bulletin 13:261-276). The PANSS measures positive symptoms, such as delusions, suspiciousness, and hallucinations; negative symptoms, such as blunted affect, social and emotional withdrawal, and stereotyped thinking; and general psychopathology, such as anxiety, tension, depression, and active social avoidance. Secondary endpoints include subscales of the PANSS and other measures to highlight key differentiating features of ITI-007. Safety and tolerability also will be assessed. About ITI-007: ITI-007 is lead drug development candidate, whose mechanisms of action, The company believes, have the potential to yield a first-in-class antipsychotic therapy. In pre-clinical and clinical trials to date, ITI-007 combines potent serotonin 5-HT2A receptor antagonism, dopamine receptor phosphoprotein modulation (DPPM), glutamatergic modulation and serotonin reuptake inhibition into a single drug candidate for the treatment of acute and residual schizophrenia. At dopamine D2 receptors, ITI-007 has been demonstrated to have dual properties and to act as both a post-synaptic antagonist and a pre-synaptic partial agonist. ITI-007 has also been demonstrated to stimulate phosphorylation of glutamatergic NMDA NR2B, or GluN2B, receptors in a mesolimbic specific manner. The company believes that this regional selectivity in brain areas thought to mediate the efficacy of antipsychotic drugs, together with serotonergic, glutamatergic, and dopaminergic interactions, may result in antipsychotic efficacy for positive, negative, affective and cognitive symptoms associated with schizophrenia. The serotonin reuptake inhibition could allow for antidepressant activity for the treatment of schizoaffective disorder, co-morbid depression, and/or as a stand-alone treatment for major depressive disorder. The company believes ITI-007 may also be useful for the treatment of bipolar disorder and other psychiatric and neurodegenerative disorders, particularly behavioral disturbances associated with dementia, autism and other CNS diseases.


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