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Change Today -0.04 / -0.65%
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immunogen inc (IMGN) Details

ImmunoGen, Inc., a biotechnology company, develops targeted anticancer therapeutics. It develops its products using its antibody-drug conjugates technology. The company offers Kadcyla, an antibody-drug conjugate for the treatment of HER2-positive metastatic breast cancer. Its product candidates include IMGN853, which is in Phase I clinical trials for the treatment of ovarian cancer, endometrial cancer, and other cancers; IMGN289 that is in Phase I clinical trials for treating squamous cell carcinoma of head and neck cancer, and non-small cell lung cancer; IMGN529, which is in Phase I clinical trials for the treatment of non-Hodgkin lymphoma and chronic lymphocytic leukemia; and IMGN779 that is in preclinical stage for treating acute myeloid leukemia. The company also develops compounds, such as AMG 172 that is in Phase I clinical trials for the treatment of clear cell renal cell carcinoma; AMG 595, which is in Phase I clinical trials for treating glioblastoma; BAY 94-9343 is in early clinical trials for the treatment of mesothelioma and ovarian cancer; BT-062 for multiple myeloma; SAR3419, which has completed Phase II clinical trials for the treatment of diffuse large B-cell lymphoma; SAR650984 that is in early clinical trials for the treatment of multiple myeloma; SAR566658 that is in Phase I clinical trials for treating CA6-positive solid tumors; and SAR408701 for solid tumors. It has collaborations with Amgen Inc.; Bayer HealthCare; Biotest AG; Eli Lilly and Company; Novartis Institutes for BioMedical Research, Inc.; the Roche Group; and Sanofi. The company was founded in 1981 and is headquartered in Waltham, Massachusetts.

307 Employees
Last Reported Date: 08/28/14
Founded in 1981

immunogen inc (IMGN) Top Compensated Officers

Chief Executive Officer, President and Direct...
Total Annual Compensation: $544.5K
Chief Financial Officer and Executive Vice Pr...
Total Annual Compensation: $245.0K
Chief Development Officer and Executive Vice ...
Total Annual Compensation: $432.4K
Executive Vice President of Distinguished Res...
Total Annual Compensation: $377.2K
Compensation as of Fiscal Year 2014.

immunogen inc (IMGN) Key Developments

ImmunoGen, Inc. Announces Executive Changes, Effective January 5, 2015

ImmunoGen, Inc. announced the appointment of Richard J. Gregory, Ph.D., as executive vice president, Research and chief scientific officer (CSO), reporting to ImmunoGen president and CEO, Daniel Junius. Dr. Gregory will join the company on January 5, 2015, at which time current CSO, John Lambert, Ph.D., will assume the position of executive vice president, distinguished research fellow. Dr. Gregory brings to ImmunoGen deep scientific and research management experience, most recently serving as senior vice president and head of research for the Sanofi Genzyme Research & Development Center. Dr. Gregory has over twenty-five years of scientific and research management experience, most of it gained in positions of increasing responsibility at Genzyme. In 2003, he was appointed the head of research at Genzyme, with responsibility for early research – from discovery to development – for all Genzyme therapeutic areas, including an ADC initiative. Following Sanofi’s acquisition of Genzyme in 2011, Dr. Gregory was appointed head of the Sanofi-Genzyme R&D Center and in that capacity was responsible for Genzyme R&D from discovery through regulatory approval. Dr. Gregory succeeds Dr. Lambert, who joined ImmunoGen in 1987 and has been the company’s CSO since 2008. Dr. Lambert assumes the newly created role of executive vice president, distinguished research fellow and remains a member of ImmunoGen’s executive team, reporting to Mr. Junius.

ImmunoGen, Inc. Presents at 33rd Annual J.P. Morgan Healthcare Conference, Jan-13-2015 09:00 AM

ImmunoGen, Inc. Presents at 33rd Annual J.P. Morgan Healthcare Conference, Jan-13-2015 09:00 AM. Venue: Westin St. Francis Hotel, San Francisco, California, United States. Speakers: Daniel M. Junius, Chief Executive Officer, President and Director.

ImmunoGen, Inc. Announces Encouraging IMGN529 Clinical Data at 56th ASH Annual Meeting and Exposition

ImmunoGen, Inc. announced the presentation of encouraging clinical findings with its IMGN529 experimental therapy for B-cell malignancies at the American Society of Hematology (ASH) annual meeting. These include objective responses at doses that were generally well tolerated. ImmunoGen's IMGN529 is a potential new treatment for DLBCL and other non-Hodgkin lymphoma (NHL) subtypes. An ADC, it comprises an antibody that targets CD37, found on B-cell malignancies, with the potent cancer cell-killing agent, DM1, attached. The antibody serves to deliver the DM1 specifically to B cells to kill them and, based on preclinical research, also contributes anticancer activity. IMGN529 is currently in the dose-finding portion of a Phase I clinical trial, which assesses increasing doses of this experimental therapy in new groups of patients with relapsed/refractory NHL. Findings with the first doses evaluated were reported previously. The IMGN529 dose levels evaluated to date range from 0.1 to 1.4 mg/kg, administered once every three weeks. Its MTD has not yet been established, and evaluation of the 1.4 mg/kg level is ongoing. 24 of the 33 patients enrolled to date were evaluable for efficacy. Ten evaluable patients had DLBCL, which had been heavily pretreated, and four (40%) of these patients had an objective response: one had a complete response (CR) and three had partial responses (PRs). The CR and one of the PRs were among patients treated with 1.0 mg/kg, a high IMGN529 dose level to complete evaluation to date. Both of these patients had received multiple prior treatments, including autologous stem cell transplant (ASCT). Ten of the 24 evaluable patients had follicular lymphoma and one of these patients also had a PR. This patient, too, had received multiple treatments including ASCT.


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