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Last $20.21 USD
Change Today +0.16 / 0.80%
Volume 210.4K
EPZM On Other Exchanges
As of 8:10 PM 04/24/15 All times are local (Market data is delayed by at least 15 minutes).

epizyme inc (EPZM) Snapshot

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08/14/14 - $40.98
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12/17/14 - $16.51
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epizyme inc (EPZM) Details

Epizyme, Inc., a clinical stage biopharmaceutical company, discovers and develops epigenetic therapies for cancer patients. Its proprietary product platform creates small molecule inhibitors of a 96-member class of enzymes known as histone methyltransferases (HMTs). The company has two HMTs inhibitors in clinical development for the treatment of patients with cancers. It is conducting a Phase I/II clinical trial of EPZ-6438, an inhibitor that targets the EZH2 HMT for the treatment of non-Hodgkin lymphoma and advanced solid tumors, including INI1-deficient tumors, such as synovial sarcoma and malignant rhabdoid tumors; and two Phase 1 clinical trials of EPZ-5676, an inhibitor targeting the DOT1L HMT for the treatment of acute leukemia with genetic alterations of the MLL gene. It has therapeutic collaborations with Celgene Corporation and Celgene International Sàrl; Eisai Co., Ltd.; and Glaxo Group Limited., as well as companion diagnostic development collaborations with Roche Molecular Systems, Inc. and Abbott Molecular Inc. Epizyme, Inc. was founded in 2007 and is headquartered in Cambridge, Massachusetts.

86 Employees
Last Reported Date: 03/12/15
Founded in 2007

epizyme inc (EPZM) Top Compensated Officers

Chief Executive Officer, President, Secretary...
Total Annual Compensation: $652.8K
Chief Scientific Officer and President of Res...
Total Annual Compensation: $531.7K
Chief Development Officer
Total Annual Compensation: $163.7K
Compensation as of Fiscal Year 2014.

epizyme inc (EPZM) Key Developments

Epizyme to Present Updated Data from Ongoing Phase 1 Dose Escalation Trial of EZH2 Inhibitor EPZ-6438 at International Conference on Malignant Lymphoma

Epizyme, Inc. announced that updated data from the Phase 1 portion of the ongoing Phase 1/2 study of EPZ-6438 will be presented during the 13thInternational Conference on Malignant Lymphoma (ICML), to be held in Lugano, Switzerland, June 17-20, 2015. EPZ-6438 is a first-in-class EZH2 inhibitor that Epizyme is currently studying in patients with advanced B-cell non-Hodgkin lymphomas (NHL) or advanced solid tumors. EZH2 is a histone methyltransferase (HMT) that is increasingly understood to play a potentially oncogenic role in a number of cancers. These include non-Hodgkin lymphomas; INI1-deficient cancers such as malignant rhabdoid tumors, epithelioid sarcomas and synovial sarcoma; and a range of other solid tumors. Epizyme is developing EPZ-6438, a small molecule inhibitor of EZH2 created with its proprietary product platform, for the treatment of non-Hodgkin lymphoma patients and patients with INI1-deficient solid tumors. In many human cancers, misregulated EZH2 enzyme activity results in misregulation of genes that control cell proliferation without these control mechanisms, cancer cells are free to grow rapidly. EPZ-6438 is the second HMTi to enter human clinical development (following Epizyme's DOT1L inhibitor, EPZ-5676).

Eisai Co., Ltd. and Epizyme, Inc. to Change the Scope of Collaboration for Their Partnership Initiated in March 2011 to Discover, Develop and Commercialize Cancer Therapeutics Targeting EZH2, an Epigenetic Enzyme

Eisai Co., Ltd. and Epizyme, Inc. have agreed to change the scope of collaboration for their partnership initiated in March 2011 to discover, develop and commercialize cancer therapeutics targeting EZH2, an epigenetic enzyme. In March 2011, Eisai and Epizyme entered into a collaboration agreement concerning the discovery, development and commercialization of cancer therapeutics targeting the epigenetic enzyme EZH2 for the treatment of non-Hodgkin B-cell lymphoma and other cancers. Under this agreement, Eisai has been conducting a phase I/II clinical study of the EZH2 inhibitor E7438 (Epizyme development code: EPZ-6438) in patients with advanced solid tumors or non-Hodgkin B-cell lymphoma. Eisai and Epizyme have revised the scope of their partnership for worldwide development and commercialization rights for anticancer therapies targeting EZH2, including E7438, with Epizyme assuming responsibility for development and commercialization in regions outside of Japan and Eisai retaining responsibility for development and commercialization within Japan as well as having the right of first negotiation for licensing rights in Asia. The decision to change the scope of the partnership was agreed upon by the two companies in consideration of the priorities of each company's pipeline strategy and the maximization of the potential value of the compounds including E7438. Based on this change in the agreement, Eisai will receive from Epizyme a contractual one-time payment as well as milestone payments as projects progress and marketing authorization is obtained. The companies will pay royalties to one another dependent upon on the sales in each company's respective sales regions after launch. Eisai considers oncology a therapeutic area of focus and is committed to the development of new anticancer agents and treatments for supportive care. Eisai strives to further contribute to addressing the diverse needs of, and increasing the benefits provided to, patients with cancer and their families.

Epizyme, Inc. Reports Unaudited Consolidated Earnings Results for the Fourth Quarter and Year Ended December 31, 2014

Epizyme, Inc. reported unaudited consolidated earnings results for the fourth quarter and year ended December 31, 2014. For the quarter, the company reported collaboration revenue of $10.349 million against $36.317 million a year ago. Loss from operations was $15.091 million against income from operations of $16.254 million a year ago. Net loss was $15.035 million against $15.930 million a year ago. Loss allocable to common stockholders was $15.035 million or $0.44 per diluted share against income allocable to common stockholders of $15.926 million or $0.52 per diluted share a year ago. For the year, the company reported collaboration revenue was $41.411 million against $68.482 million a year ago. Loss from operations was $55.050 million against $3.127 million a year ago. Net loss was $55.005 million against $3.483 million a year ago. Loss allocable to common stockholders was $55.005 million or $1.67 per diluted share against $3.747 million or $0.22 per diluted share a year ago. The decline in collaboration revenue in 2014 reflects a decline in milestone revenue, partially off-set by increased research and development services revenue.


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