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Last $26.31 USD
Change Today -0.33 / -1.24%
Volume 549.0K
As of 8:10 PM 07/2/15 All times are local (Market data is delayed by at least 15 minutes).

dyax corp (DYAX) Snapshot

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52 Week High
04/8/15 - $30.55
52 Week Low
07/18/14 - $8.09
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dyax corp (DYAX) Details

Dyax Corp., a biopharmaceutical company, identifies, develops, and commercializes treatments for hereditary angioedema (HAE) and other plasma-kallikrein-mediated (PKM) disorders. It offers KALBITOR for the treatment of acute attacks of HAE. The company distributes KALBITOR through a network of wholesale, hospital, and specialty pharmacy arrangements. It is developing DX-2930, a human monoclonal antibody inhibitor of plasma kallikrein, which is in Phase 1b clinical study to treat HAE prophylactically. The company has agreements with CVie Therapeutics to develop and commercialize KALBITOR for the treatment of HAE and other angioedema indications in China, Hong Kong, and Macau; and Novellus Biopharma AG to develop and commercialize KALBITOR for the treatment of HAE and other angioedema indications in Latin America, including Argentina, Brazil, Chile, Colombia, Mexico, and Venezuela. It also has agreement with CMIC Co., Ltd. to develop and commercialize subcutaneous ecallantide for the treatment of HAE and other angioedema indications in Japan; and collaboration agreement with Sigma-Tau Rare Diseases S.A. to develop and commercialize subcutaneous ecallantide for the treatment of HAE and other therapeutic indications in various territories worldwide. Dyax Corp. was founded in 1989 and is headquartered in Burlington, Massachusetts.

124 Employees
Last Reported Date: 02/27/15
Founded in 1989

dyax corp (DYAX) Top Compensated Officers

Chief Executive Officer, President and Direct...
Total Annual Compensation: $636.8K
Chief Financial Officer, Principal Accounting...
Total Annual Compensation: $391.9K
Chief Medical Officer and Executive Vice Pres...
Total Annual Compensation: $449.2K
Executive Vice President, General Counsel and...
Total Annual Compensation: $359.6K
Chief Commercial Officer and Executive Vice P...
Total Annual Compensation: $239.3K
Compensation as of Fiscal Year 2014.

dyax corp (DYAX) Key Developments

Dyax Corp. Announces Clinical Data from Phase Ib Hereditary Angioedema Study

Dyax Corp. has announced clinical data from a Phase Ib study with its DX-2930, an investigational fully human monoclonal antibody inhibitor of plasma kallikrein being developed for the prevention of hereditary angioedema, or HAE, attacks. The Phase Ib study results demonstrated that DX-2930 was well tolerated at all dose levels. There were no deaths or subject discontinuations due to an adverse event. There were no serious adverse events in subjects treated with DX-2930 and no evidence of dose-limiting toxicity. There was no safety signal in treatment-emergent adverse events, clinical laboratory results, vital signs, or electrocardiograms. Subcutaneous injection was well tolerated. Pharmacokinetic results demonstrated that DX-2930 has linear, dose-dependent exposure and a mean elimination half-life of approximately 14 days. Pharmacodynamic results from two different exploratory biomarker assays confirmed ex vivo plasma kallikrein inhibition in a dose- and time-dependent manner. Primary proof-of-concept efficacy analyses were based on subjects in the 300 mg, 400 mg, and placebo dose groups who reported having at least 2 attacks in the 3 months prior to study entry. During the pre-specified, primary efficacy interval of 6 weeks (from days 8 to 50; corresponding to peak drug level), the HAE attack rate was 0 in the 300 mg group and 0.045 attacks per week in the 400 mg group, compared to 0.37 attacks per week in the placebo group. This resulted in a 100% reduction for the 300 mg dose group as compared to placebo and an 88% reduction for the 400 mg dose group as compared to placebo. During this primary efficacy interval, 100% of subjects in the 300 mg group and 82% of subjects in the 400 mg group were attack-free compared with 27% of subjects in the placebo group. The Phase Ib study was a multi-center, randomized, double-blind, placebo-controlled, multiple-ascending dose study. A total of 37 subjects were randomized to active drug or placebo in a 2:1 ratio across 4 dosing groups of 30, 100, 300, or 400 mg. Each subject received two doses of DX-2930 or placebo, separated by 14 days, and was followed for 15 weeks after the second dose.

Dyax Corp. Presents at Jefferies 2015 Global Healthcare Conference, Jun-01-2015 03:00 PM

Dyax Corp. Presents at Jefferies 2015 Global Healthcare Conference, Jun-01-2015 03:00 PM. Venue: The Grand Hyatt Hotel, New York, New York, United States.

Dyax Corp. Appoints Abbie Celniker to its Board of Directors

Dyax Corp. reported the appointment of Abbie Celniker, Ph.D., to its Board of Directors. Dr. Celniker currently serves as the President and Chief Executive Officer of Eleven Biotherapeutics, where she also serves on its Board of Directors. Prior to joining Eleven Biotherapeutics, she served as the Executive Vice President, Translational Medicine of Alexion Pharmaceuticals Inc. From 2008 to 2011.


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Valuation DYAX Industry Range
Price/Earnings NM Not Meaningful
Price/Sales 40.9x
Price/Book 35.4x
Price/Cash Flow NM Not Meaningful
TEV/Sales 40.5x

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