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Last $12.22 USD
Change Today +0.20 / 1.66%
Volume 62.3K
DRNA On Other Exchanges
As of 8:10 PM 07/31/15 All times are local (Market data is delayed by at least 15 minutes).

dicerna pharmaceuticals inc (DRNA) Snapshot

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52 Week High
03/17/15 - $27.33
52 Week Low
11/6/14 - $8.00
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dicerna pharmaceuticals inc (DRNA) Details

Dicerna Pharmaceuticals, Inc., a biopharmaceutical company, focuses on the discovery and development of treatments for liver diseases and cancers based on a proprietary RNA interference technology platform in the United States and internationally. The company’s development programs include DCR-PH1 for the treatment of primary hyperoxaluria type 1 (PH1) through targeting the gene encoding the liver enzyme glycolate oxidase; and other rare inherited diseases involving genes expressed in the liver. It is also developing DCR-MYC, which is in Phase I clinical study for the treatment of various cancers in patients with solid tumors, multiple myeloma, or lymphoma, as well as in Phase Ib/II clinical trial to treat cancer in patients with advanced hepatocellular carcinoma. In addition, the company is developing KRAS oncogene, a gene that is mutated in various cancers, including non-small cell lung cancer, colorectal cancer, and pancreatic cancer; and a therapeutic targeting a second cancer-related gene. It has a license agreement with City of Hope, an academic research and medical center to manufacture, use, offer for sale, sell, and import products related to DsiRNA for the prevention and treatment of various diseases in humans; licensing and collaboration agreement with Tekmira Pharmaceuticals Corporation to license LNP delivery technology for use in PH1 development program; and a license agreement with Plant Bioscience Limited to research, discover, develop, manufacture, sell, import, and export products incorporating short RNA molecules. Dicerna Pharmaceuticals, Inc. was founded in 2006 and is headquartered in Cambridge, Massachusetts.

42 Employees
Last Reported Date: 03/12/15
Founded in 2006

dicerna pharmaceuticals inc (DRNA) Top Compensated Officers

Co-Founder, Chief Executive Officer, Presiden...
Total Annual Compensation: $430.0K
Chief Financial Officer
Total Annual Compensation: $65.4K
Chief Scientific Officer and Senior Vice Pres...
Total Annual Compensation: $335.0K
Chief Medical Officer
Total Annual Compensation: $269.1K
Chief Business Officer
Total Annual Compensation: $295.0K
Compensation as of Fiscal Year 2014.

dicerna pharmaceuticals inc (DRNA) Key Developments

Alnylam Pharmaceuticals Files Suit Against Dicerna Pharmaceuticals Alleging Theft of Trade Secrets

Alnylam Pharmaceuticals filed suit against Dicerna Pharmaceuticals alleging the rival misappropriated trade secrets related to its amino sugar derivative technology. The lawsuit was filed in state Superior Court in Massachusetts and contends Dicerna first gained access to the trade secrets when exploring a potential acquisition of Sirna Therapeutics, the one-time RNAi-research subsidiary of Merck. Alnylam eventually won that competition early last year, paying $175 million, Yet, according to the plaintiffs, Dicerna continued to pursue that technology and soon hired away several scientists from Sirna, introducing its own GalNAc-based medications less than a year later.

Dicerna Pharmaceuticals, Inc. Presents at Jefferies 2015 Global Healthcare Conference, Jun-02-2015 11:30 AM

Dicerna Pharmaceuticals, Inc. Presents at Jefferies 2015 Global Healthcare Conference, Jun-02-2015 11:30 AM. Venue: The Grand Hyatt Hotel, New York, New York, United States. Speakers: Douglas M. Fambrough, Co-Founder, Chief Executive Officer, President and Director.

Dicerna Pharmaceuticals, Inc. Announces Expansion of Ongoing DCR-MYC Phase 1 Study to Evaluate Safety and Efficacy in Patients with Advanced Pancreatic Neuroendocrine Tumors

Dicerna Pharmaceuticals, Inc. announced it is expanding its ongoing Phase 1 study of DCR-MYC in solid tumors, multiple myeloma, or lymphoma to include a cohort of patients with pancreatic neuroendocrine tumors (PNETs) following early signs of clinical and metabolic response and tumor shrinkage in PNET patients. DCR-MYC is an investigational Dicer substrate short-interfering RNA (DsiRNA) therapeutic targeting the MYC oncogene and the first MYC-targeting short-interfering RNA (siRNA) to enter clinical trials. The ongoing Phase 1 study, initiated in April 2014, is a multi-center, dose-escalation trial designed to assess the safety and tolerability of DCR-MYC in patients with solid tumors, multiple myeloma, or lymphoma who are refractory or unresponsive to standard therapies. The study is designed to identify the maximum tolerated dose (MTD), the pharmacokinetic profile, potential pharmacodynamic effects, and antitumor activity of DCR-MYC. Once the MTD is established, an expansion cohort will be opened to enroll patients with PNET. This multi-center expansion cohort will enroll up to 20 patients with low- to intermediate-grade PNET who have demonstrated disease progression after treatment with standard therapies. Preliminary safety, tolerability, clinical, and metabolic response data from the ongoing Phase 1 trial of DCR-MYC will be presented at the 2015 ASCO Annual Meeting during the Tumor Biology Oral Abstract Session on June 1, 2015.


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