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Last 10.10
Change Today -0.30 / -2.88%
Volume 39.6K
DPRM On Other Exchanges
Tel Aviv
As of 4:29 AM 04/1/15 All times are local (Market data is delayed by at least 15 minutes).

d-pharm ltd (DPRM) Snapshot

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04/3/14 - $21.38
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02/5/15 - $9.70
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d-pharm ltd (DPRM) Details

D-Pharm LTD., a drug-development company, focuses on the development of drugs for the treatment of central nervous system conditions. Its products pipeline includes DP-VPA, a generic anti-epileptic drug, which has completed the phase II clinical-stage trial for the treatment of various seizures, as well as for the treatment of manic depression and prophylaxis of migraine; and THR-18, a thrombolytic drug, which is in the Phase II clinical development for treatment of patients with acute ischemic stroke. The company is also developing DP-b99, which is in the phase II clinical stage of development for the treatment of acute high-risk pancreatitis; and DP-NDD, a novel platform technology for disease-modifying drugs for the treatment of protein-misfolding neurodegenerative disorders (NDDs), such as Alzheimer’s disease and other types of dementia, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington's disease. D-Pharm LTD. was founded in 1993 and is based in Rehovot, Israel.

Founded in 1993

d-pharm ltd (DPRM) Top Compensated Officers

Co-Founder, Chief Executive Officer and Presi...
Total Annual Compensation: 768.0K
Vice President of Finance & Human Resources
Total Annual Compensation: 456.0K
Vice President of Clinical Development
Total Annual Compensation: 558.0K
Compensation as of Fiscal Year 2013.

d-pharm ltd (DPRM) Key Developments

D-Pharm LTD. Auditor Raises 'Going Concern' Doubt

D-Pharm LTD. filed its Annual on Feb 15, 2015 for the period ending Dec 31, 2014. In this report its auditor, Kesselman & Kesselman, gave an unqualified opinion expressing doubt that the company can continue as a going concern.

D-Pharm LTD. Presents at 33rd Annual J.P. Morgan Healthcare Conference, Jan-15-2015

D-Pharm LTD. Presents at 33rd Annual J.P. Morgan Healthcare Conference, Jan-15-2015 . Venue: Westin St. Francis Hotel, San Francisco, California, United States.

D-Pharm Achieves Primary End-point in Phase 2 Clinical Study of THR-18 in Acute Stroke Patients Treated With tPA

D-Pharm Ltd. reported that its Phase 2 clinical study of THR-18 successfully achieved its primary endpoint in acute ischemic stroke (AIS) patients treated with tissue plasminogen activator (tPA). THR-18 demonstrated statistically significant reductions in the incidence of intracranial hemorrhage (ICH), brain swelling (edema) and a satisfactory safety profile. Moreover, stroke recovery was improved 2-fold in patients receiving THR-18, as judged by clinical outcome measures, 30 days following stroke. THR-18 is a novel drug-candidate designed to neutralize or reduce the life-threatening adverse effects of thrombolytic therapy with tPA. This double-blind, placebo-controlled, escalating single-dose, Phase 2 study was the first to assess the safety, pharmacodynamics and pharmacokinetics of THR-18 and tPA in AIS patients. The study has successfully defined the maximal tolerated and safe dose of THR-18 in AIS patients. The imaging data as assessed by CT (computed tomography) on day 2 following stroke and tPA treatment indicate that, in contrast to the placebo group, no patients treated with THR-18 had an intracranial hemorrhage, (p=0.02). Similarly, 0.54 mg/kg of THR-18 reduced by more than twice the occurrence of brain edema (p<0.05).   The clinical outcome following stroke was assessed using the modified Rankin Scale (mRS) and the NIH stroke scale (NIHSS); the former reflecting disability in terms of daily living and the latter neurological deficit. The efficacy data analysis indicates that 0.54 mg/kg of THR-18 doubles the recovery rate assessed both with mRS and NIHSS scales.


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