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Last $8.54 USD
Change Today -0.02 / -0.23%
Volume 72.2K
As of 8:10 PM 07/30/15 All times are local (Market data is delayed by at least 15 minutes).

chemocentryx inc (CCXI) Snapshot

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06/8/15 - $9.46
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chemocentryx inc (CCXI) Details

ChemoCentryx, Inc., a clinical-stage biopharmaceutical company, focuses on the discovery, development, and commercialization of orally administered therapeutics to treat autoimmune diseases, inflammatory disorders, and cancer in the United States. Its drug candidates in clinical development include CCX140 that has completed a Phase II clinical trial for the treatment of patients with diabetic nephropathy, a form of kidney disease; CCX872, an orally administered inhibitor that is under Phase Ib clinical trial for pancreatic cancer; and CCX168, which has completed a Phase II clinical trial for the treatment of anti-neutrophil cytoplasmic anti-body associated renal vasculitis. The company’s drug candidates in clinical development also comprise Vercirnon for the treatment of patients with moderate-to-severe Crohn’s disease; and CCX507 inhibitor, which has completed a Phase I clinical trial for the treatment of inflammatory bowel disease. Its earlier-stage programs in immuno-oncology and autoimmune diseases include CCR6 Inhibitor for autoimmune diseases; CCR4 Inhibitor for atopic autoimmune disorders; CXCR6 Inhibitor for liver diseases; CCR1 Inhibitor for inflammatory diseases and rheumatoid arthritis; and CXCR7 Inhibitor for glioblastoma multiforme. The company was founded in 1997 and is headquartered in Mountain View, California.

58 Employees
Last Reported Date: 03/13/15
Founded in 1997

chemocentryx inc (CCXI) Top Compensated Officers

Founder, Chairman, Chief Executive Officer an...
Total Annual Compensation: $550.0K
Chief Financial Officer, Senior Vice Presiden...
Total Annual Compensation: $400.0K
Chief Medical Officer
Total Annual Compensation: $384.3K
Compensation as of Fiscal Year 2014.

chemocentryx inc (CCXI) Key Developments

ChemoCentryx, Inc. Announces Positive Results from Chemocentryx Phase II Diabetic Nephropathy Trial with Chemokine Receptor CCR2 Inhibitor CCX140 Highlighted At the 52nd ERA-EDTA Congress

ChemoCentryx, Inc. announced data presentations from two of its chemoattractant receptor programs, CCR2 and C5aR, at the 52ndEuropean Renal Association – European Dialysis and Transplant Association (ERA-EDTA) Congress being held May 28 to 31 in London, UK. In a Late Breaking Clinical Trial presentation, positive 52-week data from the Company's Phase II clinical trial in patients with diabetic nephropathy with CCX140, an inhibitor of the chemokine receptor known as CCR2, were presented by Professor Dick de Zeeuw, M.D., Ph.D., Chair of the Research Section of the Department of Clinical Pharmacy and Pharmacology at the University Medical Center in Groningen, The Netherlands. Professor de Zeeuw's oral presentation focused on the CCX140 Phase II study and its primary endpoint. As previously announced, top line data from the CCX140 Phase II trial in patients with diabetic nephropathy included the following results: the trial met its primary endpoint by demonstrating that treatment with 5 mg of CCX140 given orally once daily added to a standard of care regimen (SOC) of angiotensin converting enzyme (ACE) inhibitor or angiotensin receptor II blocker (ARB) treatment resulted in a statistically significant (p=0.0148) reduction in urinary albumin:creatinine ratio (UACR), beyond that achieved with SOC alone; the maximum treatment effect was reached at 12 weeks; in patients who received 5 mg CCX140 continuously for 52 weeks, a sustained reduction in albuminuria induced by CCX140 relative to SOC alone was observed over the full year; treatment with CCX140 showed improvements in the profile of the estimated glomerular filtration rate (eGFR), represented by an attenuation in the slope of annual decline in eGFR. The treatment group receiving 5 mg of CCX140 in addition to SOC showed an attenuated annual slope decline of 1.9 mL/min/1.73 m2, compared to SOC alone group, 3.4 mL/min/1.73 m2. These results represent a 44% annualized improvement in eGFR over SOC alone; in a pre-specified sub-population in the study, patients who were highly proteinuric (baseline albuminuria levels of 800mg/g creatinine and above), a 66% annualized relative improvement in eGFR slope over SOC alone was observed; CCX140 appeared to be well tolerated with a low overall dropout rate over the 52-week treatment period. Regarding another chemoattractant receptor inhibitor program at the Company, ChemoCentryx scientists and their collaborators will outline research in atypical Hemolytic Uremic Syndrome (aHUS) and the ability of CCX168, a C5aR inhibitor, to significantly reduce the formation of platelet micro-thrombi on an ex-vivo assay system of endothelial cells. These data will be presented in a poster session on May 30th. The inhibition of micro-thrombi was dose-dependent on CCX168 and, in side-by-side experiments, the anti-thrombotic effect of CCX168 were comparable to that of eculizumab, which is the first agent approved for aHUS. The Company is initiating a CCX168 Phase IIa proof-of-concept study in aHUS patients with end stage renal disease.

ChemoCentryx, Inc. Presents at Jefferies 2015 Global Healthcare Conference, Jun-03-2015 08:00 AM

ChemoCentryx, Inc. Presents at Jefferies 2015 Global Healthcare Conference, Jun-03-2015 08:00 AM. Venue: The Grand Hyatt Hotel, New York, New York, United States. Speakers: Thomas J. Schall, Founder, Chairman, Chief Executive Officer and President.

ChemoCentryx, Inc. Reports Consolidated Earnings Results for the First Quarter Ended March 31, 2015

ChemoCentryx, Inc. reported consolidated earnings results for the first quarter ended March 31, 2015. For the quarter, the company reported loss from operations was $12,109,000 against $11,672,000 a year ago. Net loss was $12,006,000 against $11,537,000 a year ago. Basic and diluted net loss per share was $0.28 against $0.27 a year ago.


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