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Last $0.43 USD
Change Today +0.0131 / 3.14%
Volume 2.2M
As of 8:10 PM 04/24/15 All times are local (Market data is delayed by at least 15 minutes).

anavex life sciences corp (AVXL) Snapshot

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anavex life sciences corp (AVXL) Details

Anavex Life Sciences Corp., a biopharmaceutical company, is engaged in the discovery and development of drugs for the treatment of Alzheimer’s disease, central nervous system diseases, and pain and various cancers. Its lead drug candidates include ANAVEX 2-73 and ANAVEX PLUS, a combination of ANAVEX 2-73 with donepezil (Aricept), which is in a Phase IIa clinical trial for the treatment of Alzheimer’s disease. The company’s product candidates also include ANAVEX 3-71, a drug candidate that is effective in very small doses against the major Alzheimer’s hallmarks in transgenic (3xTg-AD) mice via sigma-1 receptor activation and M1 muscarinic allosteric modulation; ANAVEX 1-41, a sigma-1 agonist for neuroprotective application; and ANAVEX 1037, ANAVEX 1079, and ANAVEX 1519 for the treatment of pain and various cancers. Anavex Life Sciences Corp. was founded in 2006 and is headquartered in New York, New York.

4 Employees
Last Reported Date: 03/25/15
Founded in 2006

anavex life sciences corp (AVXL) Top Compensated Officers

Chairman, Chief Executive Officer, President,...
Total Annual Compensation: $640.0K
Compensation as of Fiscal Year 2014.

anavex life sciences corp (AVXL) Key Developments

Anavex Life Sciences Corp. Appoints Christopher Missling as Director

Anavex Life Sciences Corp. elected Christopher Missling as director for terms until the next annual meeting of stockholders or until each such director’s successor shall have been duly elected and qualified.

Anavex Life Sciences Corp. Approves Amendment to its Articles of Incorporation to Increase the Authorized Common Stock

Anavex Life Sciences Corp. approved the amendment to the company's articles of incorporation to increase the company's authorized common stock, par value of $0.001 per share (Common Stock), from 150,000,000 to 400,000,000 shares in the special meeting of stockholders held on March 26, 2015.

Anavex Life Sciences Corp. Presents Positive Results for Both ANAVEX 2-73 and ANAVEX 3-71 in Alzheimer's Models at 2015 AD/PD(TM) Conference

Anavex Life Sciences Corp. has unveiled new promising preclinical data for both ANAVEX 2-73 and ANAVEX 3-71 (formerly AF710B) in two separate presentations at the 12th International Conference on Alzheimer's and Parkinson's Diseases and Related Neurological Disorders in Nice, France. In the first presentation Tangui Maurice, PhD, a member of the Anavex Scientific Advisory Board, demonstrated for the first time the essential role of sigma-1 receptor (S1R) through S1R KO (knock out) on survival and memory in the presence of amyloid. In the transgenic amyloid expressing mouse model Tg2576, where the sigma-1 receptor (S1R) expression is impaired through S1R KO (knock out), at 12 months the survival was reduced by 50% compared to the non-S1R KO Tg2576 model. Apparently the genetic inactivation of the S1R gene worsens amyloid toxicity and has a detrimental impact on survival and also memory impairment. Amyloid is believed to play a key role in the development of the symptoms of Alzheimer's disease (AD). On the other hand, activation of the S1R through treatment with the S1R agonist ANAVEX 2-73 in the Tg2576 model alleviates amyloid toxicity and resulting learning deficits both after one month and two months daily oral treatment, respectively. In addition expression of ROS (reactive oxidative species) as well as plasticity related IEG and transcription factors in the mouse hippocampus were clearly negatively impacted through the S1R KO, however, were significantly improved through ANAVEX 2-73. This confirms that targeting the S1R, a key factor in brain plasticity, may demonstrate neuroprotection in Alzheimer's disease. ANAVEX 2-73 is currently undergoing a Phase 2a trial in Alzheimer's patients. In the second presentation Abraham Fisher, PhD, a member of the Anavex Scientific Advisory Board, demonstrated for the first time data showing that ANAVEX 3-71 rescued mushroom synaptic or spine loss in hippocampal neurons of wild type and two mouse models of AD. The effects of ANAVEX 3-71 appear specific since a pure M1 muscarinic agonist was less potent or not effective in the tested neuronal cultures, respectively. Further evidence was provided that ANAVEX 3-71 reduced soluble and insoluble Abeta1-40, Abeta1-42 and Abeta plaques in the 3xTg-AD animal model as well as decreased BACE1 expression. It was further demonstrated that ANAVEX 3-71 also decreased tau phospho-epitopes AT100, AT8 AT180, AT270, PHF-1 and decreased kinases inducing tau-hyperphosphorylation (p25/Cdk5 & GSK3beta) and mitigated cognitive impairments in the 3xTg-AD animal model. Cdk5 activator protein p25 preferentially binds and activates GSK3beta. Increased Cdk5/p25 expression has been demonstrated in the brains of patients with Alzheimer's and Parkinson's diseases and several other CNS diseases. Hence, ANAVEX 3-71 may restore synaptic homeostasis, by decreasing p25 and inhibiting GSK3beta & Cdk5. It was further shown that ANAVEX 3-71 decreased the number of 6E10 positive Abeta1-42, activated astrocytes (GFAP) and microglia (Iba-1). The decrease in these inflammatory cell markers is likely a consequence of reduced Abeta in the brain, although any beneficial direct effect of the drug on inflammation might be possible. It is believed that the effects of ANAVEX 3-71 are mediated by a concomitant activation of the M1 muscarinic receptor (M1R) and the S1R via an induced hypothetical heteromerization between M1R & S1R. ANAVEX 2-73 is currently undergoing a Phase 2a trial in Alzheimer's patients after completing a Phase 1 study with a clean data profile. In earlier preclinical studies, ANAVEX 2-73 showed potential to halt and/or reverse Alzheimer's disease. Additionally, positive preclinical data reveals the potential for ANAVEX 2-73 as a platform drug to treat additional CNS disorders, including epilepsy. ANAVEX 3-71, previously AF710B, is a unique and promising preclinical drug candidate with a novel mechanism of action shown to enhance neuroprotection and cognition in Alzheimer's disease. It is a CNS-penetrable mono-therapy that bridges treatment of both cognitive impairments with disease modifications. ANAVEX 3-71 is highly effective in very small doses against the major Alzheimer's hallmarks in transgenic (3xTg-AD) mice, including cognitive deficits, amyloid and tau pathologies, and also has beneficial effects on inflammation and mitochondrial dysfunctions.


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