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Last $1.71 USD
Change Today +0.08 / 4.91%
Volume 143.7K
ARQL On Other Exchanges
As of 8:10 PM 07/31/15 All times are local (Market data is delayed by at least 15 minutes).

arqule inc (ARQL) Snapshot

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03/9/15 - $2.50
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10/15/14 - $1.04
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arqule inc (ARQL) Details

ArQule, Inc., a clinical-stage biotechnology company, researches and develops therapeutics for the treatment of cancer and rare diseases. Its lead product candidate is tivantinib, a small molecule inhibitor of the c-Met receptor tyrosine kinase and its biological pathway, which is in Phase III clinical trial for the treatment of liver cancer and non-small cell lung cancer; Phase II clinical trial for the treatment of mesothelioma and kidney cancer; and Phase I clinical trial for the treatment of pediatric tumors, as well as has completed Phase II clinical trial for the treatment of colorectal cancer. The company’s early clinical-stage products in Phase Ib clinical trials include ARQ 092, an inhibitor of the AKT serine/threonine kinase; ARQ 087, a multi-kinase inhibitor of the fibroblast growth factor receptor (FGFR) family for patients with cholangiocarcinoma and adrenocortical tumors, as well as with FGFR translocations, amplification, and mutations; and ARQ 761, an intravenously administered analogue of Beta-lapachone, which is used as a promoter of NQ01-mediated programmed cancer cell necrosis. Its pre-clinical development program also includes ARQ 751, a next-generation inhibitor of AKT. ArQule, Inc. has partnership agreement with Daiichi Sankyo Co., Ltd. to conduct research, clinical trials, and the commercialization of tivantinib for human cancer indications in the United States, Europe, South America, and internationally; and Kyowa Hakko Kirin Co., Ltd. to develop and commercialize tivantinib in Japan and parts of Asia. The company has collaboration agreement with the National Human Genome Research Institute of the NIH for a clinical trial investigating on ARQ 092, which is used for the treatment of Proteus syndrome. ArQule, Inc. was founded in 1993 and is headquartered in Burlington, Massachusetts.

40 Employees
Last Reported Date: 05/6/15
Founded in 1993

arqule inc (ARQL) Top Compensated Officers

Chief Executive Officer and Director
Total Annual Compensation: $489.3K
President, Chief Operating Officer, General C...
Total Annual Compensation: $413.9K
Chief Medical Officer and Senior Vice Preside...
Total Annual Compensation: $394.6K
Compensation as of Fiscal Year 2014.

arqule inc (ARQL) Key Developments

ArQule Announces Interim Phase 2 Study Results for Tivantinib in Combination with Cetuximab in Patients with MET-High, KRAS Wild Type Colorectal Cancer

ArQule Inc. announced interim data from an ongoing investigator-initiated Phase 2 clinical trial with tivantinib in combination with cetuximab in patients with MET-High, KRAS wild-type metastatic colorectal cancer (CRC) NCT01892527 who recently progressed on anti-EGFR antibodies. These data were presented on July 3rd at the European Society of Medical Oncology (ESMO) World GI 2015 (abstract number O-008) by Dr. Lorenza Rimassa, MD, Deputy Director, Medical Oncology Unit at Humanitas Cancer Center, in Rozzano (Milan, Italy). The primary endpoint of the trial is ORR in the biomarker defined population. Secondary study endpoints are progression-free survival (PFS), overall survival (OS) and safety. The ESMO World GI presentation included data from 21 patients enrolled in Stage 1 of this trial. One patient, still on therapy, experienced a complete response (CR) and 2 patients experienced durable confirmed partial responses (PRs). Stable disease was observed in 8 patients, including 2 short duration PRs, for an overall Disease Control Rate (CR + PR + SD) of 52.4%. Having met the Stage 1 endpoint (=2 confirmed responses), the trial continued to Stage 2 and has recently completed enrollment. Adverse events were in line with those historically reported, including skin toxicity attributed to cetuximab, and neutropenia attributed to tivantinib. Neutropenia was addressed timely with growth factors and dose adjustments. The trial is a 2-stage, investigator-initiated study testing tivantinib plus cetuximab after recent progression on anti-EGFR antibodies. The trial is coordinated by the Humanitas Cancer Center in Milan, Italy. Stage 1 enrolled 21 patients, and Stage 2 recently completed enrollment of 20 additional patients. Final results from the 41 patients enrolled are expected by the end of 2015.

ArQule Inc. Appoints Robert J. Weiskopf as Chief Financial Officer

ArQule Inc. announced that Robert J. Weiskopf has been appointed chief financial officer. Mr. Weiskopf was previously vice president of finance, corporate controller and treasurer of the company. He will retain the title of treasurer and continue to report to Paolo Pucci, chief executive officer of the company. Prior to joining the company in 2007, Mr. Weiskopf was chief financial officer of Aware Inc. from 2004 until 2006. Prior to that, Mr. Weiskopf was director of finance at Lightbridge Inc. from 2000 to 2004.

ArQule Inc. Presents at Jefferies 2015 Global Healthcare Conference, Jun-03-2015 10:30 AM

ArQule Inc. Presents at Jefferies 2015 Global Healthcare Conference, Jun-03-2015 10:30 AM. Venue: The Grand Hyatt Hotel, New York, New York, United States.


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Price/Sales 9.4x
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