Last $0.61 USD
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arno therapeutics inc (ARNI) Details

Arno Therapeutics, Inc., a development stage company, focuses on developing products for the treatment of cancer. Its product development pipeline includes Onapristone, a type 1 anti-progestin hormone blocker, which is in Phase I dose escalation clinical trial in post-menopausal women for the treatment of breast, endometrial, and others solid tumors; and Phase I/II clinical trial in men for the treatment of advanced castration-resistant prostate cancer. The company also develops AR-42, an orally available spectrum inhibitor of histone and non-histone deacetylation proteins that is in Phase I/IIa clinical study for the treatment of hematological malignancies and solid tumors; and AR-12, an orally available targeted anti-cancer agent, which has completed Phase I clinical study for the treatment of solid tumors and hematological malignancies. It has a collaboration and licensing agreement with Leica Biosystems Newcastle Ltd. for developing a companion diagnostic for Onapristone; and licensing agreement with Invivis Pharmaceuticals, Inc. Arno Therapeutics, Inc. is based in Flemington, New Jersey.

7 Employees
Last Reported Date: 05/15/14

arno therapeutics inc (ARNI) Top Compensated Officers

Chief Executive Officer, Chief Medical Office...
Total Annual Compensation: $591.6K
Chief Development Officer
Total Annual Compensation: $311.8K
Compensation as of Fiscal Year 2013.

arno therapeutics inc (ARNI) Key Developments

Arno Therapeutics, Inc. Presents at Noble Financial Capital Markets Eleventh Annual Investor Conference, Jan-20-2015 04:00 PM

Arno Therapeutics, Inc. Presents at Noble Financial Capital Markets Eleventh Annual Investor Conference, Jan-20-2015 04:00 PM. Venue: Club Med, Sandpiper Bay, Florida, United States. Speakers: Lawrence A. Kenyon, Chief Financial Officer, Chief Operating Officer and Principal Accounting Officer.

Arno Therapeutics to Present Data Further Validating Diagnostic Development of CDx for Onapristone at San Antonio Breast Cancer Symposium 2014

Arno Therapeutics, Inc. announced that data from a study supporting diagnostic development for its lead compound onapristone will be presented at a poster session at the 2014 San Antonio Breast Cancer Symposium (SABCS), being held December 9-13, 2014 in San Antonio, Texas. The study evaluated the impact of using a progesterone receptor (PR) isotype-specific immunohistochemical (IHC) diagnostic technique on the diagnosis of triple-negative breast cancer tumors, which are defined as estrogen receptor (ERα), PR and HER2 negative. PR cellular expression is thought to be linked to ERα expression in breast cancer. Triple-negative breast cancer may express PR when tested with two forms of the PR: PRA and PRB antibodies. Routine IHC determination of PR utilizes "bispecific" antibodies which recognize epitopes common to both PRA and PRB. Ultimately, the accuracy of triple-negative phenotype determination depends in part on the ability of the antibody to detect both PRA and PRB expression in the tumor. The study evaluated 775 archived breast cancer tumor samples from female patients diagnosed with invasive ductal breast cancer provided by Oscar Lambret Hospital in Lille, France. The samples were analyzed for ERα, PRA and PRB. Of the samples, 89 cases were determined to be ERα negative (by retesting) and HER2 negative (from patient records). Evaluating the PR status with IHC staining demonstrated that 53 of the 89 cases (60%) were found to be 'true' triple negative using isotype specific antibodies for PRA and PRB. Furthermore, results showed that 21 of the 89 (24%) were PR positive using the PRA and PRB antibodies tested and 15 of the 89 (17%) were found to be PR positive with either the PRA or PRB antibody and not with the PR bispecific antibody used in standard PR testing. The use of PRA and PRB isotype-specific antibodies may reveal breast cancer cases that are not necessarily triple negative.

Arno Therapeutics, Inc. Announces Management Changes

Arno Therapeutics, Inc. announced that it has appointed Alexander Zukiwski, M.D. to its board of directors. The board of directors also appointed Dr. Zukiwski as the company's chief executive officer. Dr. Zukiwski, who had served as the company's interim CEO since July 2014, will also continue in his role as its chief medical officer. In addition to Dr. Zukiwski's appointment, the company announced that Randy Thurman has resigned from the company's board of directors.


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