Last SFr.3.20 CHF
Change Today -0.08 / -2.44%
Volume 61.1K
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addex pharmaceuticals ltd (ADXN) Snapshot

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Day High
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52 Week High
07/4/14 - SFr.5.24
52 Week Low
05/5/14 - SFr.1.28
Market Cap
Average Volume 10 Days
Shares Outstanding
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addex pharmaceuticals ltd (ADXN) Details

Addex Therapeutics Ltd., together with its subsidiaries, is engaged in the discovery, development, and commercialization of small-molecule pharmaceutical products for the treatment of human health. The company’s lead products include dipraglurant ADX48621, a metabotropic glutamate receptor (mGluR) 5 negative allosteric modulator that is in Phase IIa clinical trial for the treatment of Parkinson’s disease levodopa-induced dyskinesia; and ADX71149, an mGluR2 positive allosteric modulator (PAM), which is under Phase IIa clinical trial to treat schizophrenia and anxiety. It also develops various preclinical programs comprising GABA-BR PAM for overactive bladder and other disorders; mGluR4 PAM for the treatment of Parkinson’s, multiple sclerosis, and other diseases; GLP1R PAM for type 2 diabetes; and mGluR2 NAM for treating Alzheimer's disease and depression. In addition, the company has discovery programs to identify allosteric modulators, including TrkB PAM for neurodegenerative diseases; and TNFR1 NAM for inflammatory diseases. The company’s product under development also includes ADX71441 for the treatment of alcohol addiction, Charcot-Marie-Tooth disease, and other indications. It has license and collaboration agreement with Janssen Pharmaceuticals Inc. to develop mGlu2PAM compounds for the treatment of human health. The company was formerly known as Addex Pharmaceuticals Ltd. and changed its name to Addex Therapeutics Ltd. in March 2012. Addex Therapeutics Ltd. was founded in 2002 and is headquartered in Geneva, Switzerland.

5 Employees
Last Reported Date: 05/31/14
Founded in 2002

addex pharmaceuticals ltd (ADXN) Top Compensated Officers

Chief Executive Officer
Total Annual Compensation: SFr.358.9K
Compensation as of Fiscal Year 2013.

addex pharmaceuticals ltd (ADXN) Key Developments

Addex Therapeutics and Dystonia Medical Research Foundation Announce Partnership to Explore the Therapeutic Use of Dipraglurant in the Treatment of Dystonia

Addex Therapeutics and the Dystonia Medical Research Foundation announced entering a collaboration to explore the use of dipraglurant to treat dystonia, the third most common movement disorder following essential tremor and Parkinson's disease. Dipraglurant, a novel small molecule inhibitor of the metabotropic glutamate receptor 5, has shown promise in the treatment of levodopa-induced dyskinesia and dystonia in Parkinson's disease. Dipraglurant has also been shown to normalize the effects of the TOR1A/DYT1 dystonia mutation in the brains of mice. The objective of the collaboration is to design a detailed development plan and regulatory path as well as identifying key option leaders and patients for a Phase 2 clinical trial. In addition, Addex recently reported on 9 January, plans to start clinical testing of the therapeutic effect of dipraglurant in patients with cervical dystonia in collaboration with Professor Dirk Dressler of The Hannover Medical School.

Addex Amends mGlu2PAM Collaboration Agreement and Receives USD 757,000

Addex Therapeutics announced that it has received USD 757,000 from Janssen Pharmaceuticals Inc., following the amendment of their mGlu2PAM research collaboration and license agreement. Under the agreement signed between Addex and Janssen in 2004, Addex was required to finance 50% of the cost of all jointly owned patents. Under this amendment, certain jointly owned patents have been assigned to Janssen and all past patent costs paid by Addex have been reimbursed by Janssen to Addex. Going forward, Addex contribution to patent costs has been significantly reduced. This amendment has no impact on Addex right to receive royalties and milestones under the agreement.

Addex Therapeutics Enters in to Collaboration with Charcot-Marie-Tooth Association to Evaluate the Pharmacology of ADX71441

Addex Therapeutics announced entering a collaboration with the Charcot-Marie-Tooth Association (CMTA) to evaluate the pharmacology of ADX71441, a GABA-B receptor positive allosteric modulator (PAM) in a battery of preclinical models of Charcot-Marie-Tooth 1A disorder (CMT1A), a rare hereditary motor and sensory demyelinating peripheral neuropathy. The CMTA consortium will evaluate the efficacy of ADX71441 as a pharmacological agent in preclinical neurological and behavioral models of CMT1A and will assess the potential of ADX71441 to impede the development of motor and sensory control defects associated with normal disease progression. Both clinical and pre-clinical data suggest that activation of GABA-B receptors offers a unique therapeutic opportunity to address the needs of patients with CMT1A. Addex has previously announced a positive proof of concept in a validated pre-clinical model of Charcot-Marie-Tooth 1A (CMT1A) with ADX71441, confirming previous observations obtained using a GABA-B receptor agonist and the GABAB1-/- knock-out mice. This model identified the importance of GABA-B receptors in inhibiting proliferation and reduction of synthesis of specific myelin proteins, in particular, in lowering the toxic PMP22 overexpression, which in turn, may delay disease progression.


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