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Last ¥3,720 JPY
Change Today -55.00 / -1.46%
Volume 755.5K
As of 2:00 AM 04/17/15 All times are local (Market data is delayed by at least 15 minutes).

chugai pharmaceutical co ltd (4519) Snapshot

Open
¥3,765
Previous Close
¥3,775
Day High
¥3,770
Day Low
¥3,705
52 Week High
08/18/14 - ¥4,015
52 Week Low
04/24/14 - ¥2,501
Market Cap
2.1T
Average Volume 10 Days
883.5K
EPS TTM
¥93.53
Shares Outstanding
559.7M
EX-Date
06/26/15
P/E TM
39.8x
Dividend
¥52.00
Dividend Yield
1.29%
Current Stock Chart for CHUGAI PHARMACEUTICAL CO LTD (4519)

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chugai pharmaceutical co ltd (4519) Details

Chugai Pharmaceutical Co., Ltd. manufactures, sells, imports, and exports pharmaceutical products in Japan and internationally. Its products in oncology include Avastin, Herceptin, Rituxan, Xeloda, Tarceva, Neutrogin, Perjeta, Kadcyla, and Alecensa; bone and joint disease products comprise Actemra, Suvenyl, Edirol, Alfarol, and Bonviva; renal disease products consist of Mircera, Oxarol, and Epogin; and other products, such as Tamiflu, Sigmart, CellCept, Pegasys, and Copegus. The company has various development product candidates in the areas of oncology, bone and joint diseases, autoimmune diseases, central nervous system, and other diseases. Chugai Pharmaceutical Co., Ltd. has a strategic alliance with Roche; co-development agreement with Taisho Pharmaceutical Co., Ltd.; and license agreement and collaboration with Athersys, Inc. The company was founded in 1925 and is headquartered in Tokyo, Japan. Chugai Pharmaceutical Co., Ltd. is a subsidiary of Roche Holding Ltd.

7,023 Employees
Last Reported Date: 04/1/15
Founded in 1925

chugai pharmaceutical co ltd (4519) Top Compensated Officers

Chairman and Chief Executive Officer
Total Annual Compensation: ¥266.0M
President, Chief Operating Officer and Repres...
Total Annual Compensation: ¥74.0M
Compensation as of Fiscal Year 2013.

chugai pharmaceutical co ltd (4519) Key Developments

Chugai Pharmaceutical Co., Ltd. and Taisho Pharmaceutical Co., Ltd. Announce Positive Results from Phase III Osteoporosis Trial

Chugai Pharmaceutical Co., Ltd. and Taisho Pharmaceutical Co., Ltd., have announced positive results from Japanese Phase III clinical trial of a bisphosphonate antiresorptive agent, ibandronate sodium hydrate oral agent, which is currently co-developed by Chugai and Taisho in Japan for the anticipated indication of osteoporosis. The MOVEST study, a randomized, multi center, double-blind, parallel group, controlled study, was conducted in approximately 400 patients (over 55 years of age) with osteoporosis to assess efficacy and safety of ibandronate oral formulation 100mg against ibandronate sodium hydrate injection [brand name: Bonviva IV Injection 1 mg Syringe (ibandronate injection)]. The increase in bone mineral density (BMD) of the lumbar spine (L2-L4) (percentage of relative change from baseline) at twelve month, the study's primary endpoint, was 5.22% for ibandronate oral formulation, and 5.34% [ 95% CI: 4.78% - 5.90% ] for ibandronate injection, respectively. The difference between the rate of change for ibandronate injection group of ibandronate oral formulation group (least squeares meane) was -0.23. It met the protocol criteria, a non-inferiority of ibandronate oral formulation to ibandronate injection has been demonstrated. The secondary endpoints of BMD gains in femur and inhibition on bone metabolic markers also showed similar effects between the two groups. No new safety signals were observed in the study. The safety profile was consistent with the previous overseas study results, and well tolerability of ibandronate oral formulation in osteoporotic patients was observed. Chugai filed a new drug application to the Ministry of Health, Labour and Welfare in February 2015, based on above and other data. Chugai and Taisho have been co-developing ibandronate oral formulation and Bonviva IV Injection in Japan as new treatment options for osteoporosis that improve adherence and offer patients wider choice of administration routes in Japan. Chugai and Taisho Toyama Pharmaceutical Co., Ltd. have been co-marketing Bonviva IV Injection, developed ahead of ibandronate oral formulation, since August, 2013 after Chugai obtained approval for osteoporosis indication in June, 2013. Following Bonviva IV Injection, Chugai and Taisho are determined to make efforts to obtain early approval of ibandronate oral formulation, a monthly oral agent and supply to patients and healthcare professionals.

Chugai Pharmaceutical Co. Ltd. Presents at 12th Annual BIO Asia International Conference, Mar-24-2015 01:00 PM

Chugai Pharmaceutical Co. Ltd. Presents at 12th Annual BIO Asia International Conference, Mar-24-2015 01:00 PM. Venue: Grand Hyatt Hotel, Tokyo, Japan.

Athersys, Inc. and Chugai Pharmaceutical Co., Ltd. Announce Partnership and License Agreement to Develop MultiStem(R) Cell Therapy for Ischemic Stroke in Japan

Athersys, Inc. and Chugai Pharmaceutical Co. Ltd. announced a partnership and license agreement to exclusively develop and commercialize MultiStem cell therapy for ischemic stroke in Japan. Ischemic stroke represents a priority disease area in Japan, given the high healthcare burden of the condition and the expected increase in incidence associated with Japan's aging population. Athersys' proprietary cell therapy product, MultiStem, is currently being evaluated in a Phase 2 clinical study for ischemic stroke in the United States and Europe, and Athersys has begun preparations for clinical development in Japan, including engagement with the Japanese Health Authority. Chugai is a leading research-based pharmaceutical company with strengths in biotechnology products, and brings to the collaboration substantial expertise and experience in late-stage development and commercialization in Japan. As part of the collaboration, Chugai will be responsible for the development and commercialization of MultiStem for ischemic stroke in Japan, and Athersys will have responsibility for product supply. Under the financial terms of the agreement, Athersys will receive an up-front cash payment of $10 million from Chugai and would receive additional payments as the program is further advanced. Athersys is eligible to receive milestone payments from Chugai of up to $45 million upon the successful achievement of certain development and regulatory milestones, and sales milestones of up to 17.5 billion Yen (approximately $150 million based on the current exchange rate). Athersys would also receive from Chugai tiered, double-digit royalties on any net sales, as well as payments for product supplied to Chugai. In Athersys' ongoing Phase 2 clinical study, it is evaluating the administration of MultiStem cell therapy to patients who have suffered an ischemic stroke. Based on preclinical research to date, administration of MultiStem has shown significant benefits through several mechanisms, including reduction of inflammation and immune system modulation in the ischemic area, and the protection and rescue of damaged or injured cells, including neuronal tissue. Athersys is treating patients one to two days after the stroke has occurred, in contrast to thrombolytic tPA treatment, which is limited to the first three to four hours following the stroke. Preclinical studies have demonstrated that administration of a single dose of MultiStem therapy, even one week after a stroke, provides significant and durable improvements relative to controls. Enrollment in Athersys' double-blind, placebo-controlled trial is complete, and interim safety and initial efficacy results following the ninety-day patient data are expected to be announced in April 2015, following analysis and receipt of the unblinded clinical data.

 

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