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eisai co ltd (4523) Details

Eisai Co., Ltd. manufactures and sells pharmaceutical products worldwide. The company offers oncology-related products, such as Halaven, an anticancer agent; Aloxi, an antiemetic agent; and Fragmin, an injectable anticlotting agent, as well as Symbenda/Treakisym, a treatment for low-grade non-Hodgkin's lymphoma and other types of lymphatic cancer. It also provides Aricept, an anti-Alzheimer's agent; Pariet/AcipHex, a proton-pump inhibitor; and Humira, a human anti-TNF-a monoclonal antibody. In addition, the company offers epilepsy products comprising Zonegran, Zebinix, and Fycompa, which are antiepileptic agents; and Inovelon/BANZEL for the treatment of Lennox-Gastaut syndrome, as well as consumer healthcare (over-the-counter) products, which include vitamin B2 preparation Chocola BB Plus. Further, it provides Methycobal, a peripheral neuropathy treatment; Warfarin, an oral anticoagulant; Actonel, an osteoporosis treatment; Selbex for the treatment of gastritis/gastric ulcer; BELVIQ, an antiobesity agent; Stronger Neo-Minophagen C/Glycyron tablets for liver disease/allergic disease treatment; Lyrica, a treatment for postherpetic neuralgia; and Lunesta, a treatment for insomnia. Additionally, the company is involved in the research and development of various products under the areas of oncology, vascular and immunological reaction, gastrointestinal and hepatic disorders, and neurology. It has strategic partnerships with Quintiles Inc.; SFJ Pharma Ltd.; Biogen Idec, Inc.; BioArctic Neuroscience AB; FORMA Therapeutics, Inc.; Epizyme, Inc.; PRISM BioLab Co., Ltd.; and Verastem, Inc. for the discovery and development of various products. The company was formerly known as Nihon Eisai Co., Ltd. and changed its name to Eisai Co., Ltd. in 1955. Eisai Co., Ltd. was founded in 1941 and is headquartered in Tokyo, Japan.

10,419 Employees
Last Reported Date: 06/20/14
Founded in 1941

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eisai co ltd (4523) Key Developments

Eisai Co., Ltd. Receives Approval of a New Indication for Proton Pump Inhibitor Pariet® Tablets 10 mg in Japan

Eisai Co., Ltd. announced that it has received approval of a new indication for proton pump inhibitor Pariet® Tablets 10 mg (rabeprazole sodium, “Pariet”) in Japan for use in the prevention of recurrent gastric or duodenal ulcers caused by low-dose aspirin therapy. In addition, Eisai has also received approval of a 5 mg tablet formulation with the same indication as Pariet Tablets 10 mg. The data used in the application was from a Phase II/III study (Study 308 /Study 309) on patients who required long-term administration of low-dose aspirin and who were confirmed to also have a history of gastric or duodenal ulcers. The results of Study 308 showed that cumulative recurrence rates of gastric or duodenal ulcers over 24 weeks (the study's primary endpoint) in the 5 mg and 10 mg Pariet groups were 2.8% and 1.4%, respectively, compared to 21.7% for the comparator group (teprenone). Thus, both Pariet groups demonstrated a significantly better preventative effect than the comparator group (p<0.001 for both Pariet groups vs. the comparator group) 1 . Furthermore, in Study 309 which examined the long term administration of Pariet 5 mg and 10 mg for a maximum of 52 weeks after initial treatment of 24 weeks, both dosage groups maintained a preventative effect over the whole 76 week maximum treatment period. The most commonly reported side effects (5 or more cases observed) in both Study 308 and 309 were diarrhea and constipation, and this was consistent with the known safety profile of Pariet. In addition, the registration validity period for this indication for Pariet is 4 years. By gaining this approval, Eisai aims to increase the clinical value of the drug so as to further contribute to the range of treatment options available to patients with acid-related diseases.

Eisai Co., Ltd. Presents New Phase III Data at the American Epilepsy Society Annual Meeting in Seattle, Washington

Eisai Co., Ltd. presents new Phase III data at the American Epilepsy Society (AES) Annual Meeting in Seattle, Washington, of Fycompa® (perampanel) as adjunctive therapy for primary generalised tonic-clonic seizures (PGTC). Perampanel is currently indicated for the adjunctive treatment of partial onset seizures, with or without secondarily generalised seizures, in patients with epilepsy aged 12 years and older. Perampanel is the only licensed anti-epileptic drug (AED) to selectively target AMPA receptors, a protein in the brain which plays a critical role in the spread of seizures. This mechanism of action is different to all other, currently available AEDs. In addition, perampanel has the added benefit of convenient, once-daily dosing at bedtime and, significantly, is the only new-generation partial epilepsy treatment approved to treat adolescents (>12 years) with epilepsy from launch. The results from study 332 demonstrate that perampanel significantly reduces primary generalised tonic-clonic seizure frequency and improves responder rates (=50% reduction in seizure frequency per 28 days in the maintenance period, relative to baseline), the study's two primary outcome measures, when compared to placebo. The study showed that adjunctive treatment with perampanel improved seizure control in people with idiopathic generalised epilepsy aged 12 years and over who were living with inadequately controlled primary generalised tonic-clonic seizures. 30.9% using perampanel were free of tonic-clonic seizures and it was well tolerated with a safety profile similar to refractory partial-onset seizures. Discovered and developed by Eisai in Europe and Japan, perampanel is manufactured in the UK and was approved by the European Commission on 23 July 2012. Perampanel is now approved in more than 35 countries worldwide. Eisai submitted a Marketing Authorisation Application to the European Commission in August 2014 for an indication expansion for perampanel to include the adjunctive treatment of PGTC seizures in people with epilepsy.

Eisai Co., Ltd. Establishes Holding Company Eisai China Holdings Ltd. in China

Eisai Co., Ltd. announced that it has established a holding company Eisai China Holdings Ltd. in Suzhou, Jiangsu Province, China. Eisai China Holdings Ltd. is a subsidiary of Eisai Asia Regional Services Pte. Ltd. which is Eisai's representative subsidiary for Asia located in Singapore. With the establishment of this new company, Eisai China Holdings Ltd. will integrate the Chinese domestic subsidiaries Eisai China Inc. and Eisai (Suzhou) Trading Co. Ltd., strengthen various functions including accounting, legal and compliance, and also create a flexible capital transfer system to respond to capital demands, in order to optimize the management of business in China. It is expected to achieve strong double digit growth into the future. Through the establishment of Eisai China Holdings Ltd., Eisai plans to further enhance its pharmaceutical production, sales and supply systems in China, and through the stable supply of high quality pharmaceutical products together with the provision of accurate information, strives to fulfill the diverse needs of patients and their families in China.


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