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September 03, 2015 7:29 PM ET

Biotechnology

Company Overview of Regentis Biomaterials Ltd.

Company Overview

Regentis Biomaterials Ltd., a tissue repair company, develops and commercializes biodegradable hydrogels for the repair of damaged cartilage tissue. It offers GelrinC, a biodegradable hydrogel platform for the repair of cartilage defects that include micro fracture, mosaicplasty, osteochondral autologous (or autograft) transplantation system, and autologous chondrocyte implantation, as well as for the treatment of painful injuries to articular knee cartilage; and Gelrin, a hydrogel matrix of polyethylene glycol diacrylate (PEG-DA) and denatured fibrinogen that combines the stability and versatility of a synthetic material with the bio-functionality of a natural substance. The company was fou...

12 Ha’ilan Street

Northern Industrial Zone

P.O.Box 260

Or-Akiva,  3060000

Israel

Founded in 2004

Phone:

972 4 626 5502

Fax:

972 4 626 5504

Key Executives for Regentis Biomaterials Ltd.

Chief Executive Officer and President
Age: 63
Co-Founder and Chief Scientific Officer
Vice President of Business Development and General Manager of Israel Office
Vice President of Research & Development
Clinical Advisor
Compensation as of Fiscal Year 2015.

Regentis Biomaterials Ltd. Key Developments

Regentis Biomaterials Announces Clinical Data of Gelrinc Implant for Treating Articular Cartilage in Injured Knees

Regentis Biomaterials announced a new clinical data demonstrating the efficacy and safety of its GelrinC implant for treating articular cartilage in injured knees. As presented at the International Cartilage Repair Society World Congress in Izmir, Turkey, the clinical results demonstrated sustained knee function improvement over 24 months after implantation and significant pain reduction. In addition, the clinical safety data showed that adverse effects were limited and comparable to those reported in similar studies with no serious adverse events related to the implant. Articular cartilage is the smooth, white tissue covering the ends of bones where they come together to form joints. In the knee, this cartilage can be damaged by a traumatic sports accident or a bad fall. A painful injury for patients, repairing articular cartilage is a challenge for doctors to treat since the tissue has no capacity to heal itself. GelrinC is a biodegradable hydrogel implant designed to treat cartilage defects in the knee. It is administered as a liquid to fill any shape of cartilage defect and it is then converted into a solid after 90 seconds of exposure to ultra-violet light. The GelrinC implant naturally degrades within 6-12 months and is replaced with functional and durable cartilage. After two years of study, patients had a substantial improvement of the Knee injury and Osteoarthritis Outcome Score (KOOS), excluding the sports subscale, of 23.6 points at 18 months, representing a 43% improvement, and 32.9 points at 24 months, representing a 60% improvement (52.6 vs. 84.1). KOOS is a patient-reported outcome measurement instrument developed to assess a patient's opinion about their knee and associated problems. Scores from the international knee documentation committee (IKDC), another measure of patient progress, were even more impressive. The subjective questionnaire showed an improvement of 86% at 18 months and 94% at 24 months (40.4 vs. 78.4). The clinical results came from a single-arm, multi-center study that involved 23 patients in Europe and Israel. An additional 30 patients are currently enrolled at 12 new sites in Germany, Belgium, Poland, the Netherlands and Israel. CE mark-approved, GelrinC is an investigational device and is not available for sale in the U.S. and Israel.

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