March 05, 2015 9:30 PM ET

Life Sciences Tools and Services

Company Overview of Sage Science, Inc.

Company Overview

Sage Science, Inc. develops laboratory instruments and consumables for life sciences research and diagnostic laboratory markets in the United States. It offers BluePippin DNA size selection system, a preparative electrophoresis platform that separates and extracts DNA fragments; Pippin Prep DNA size separation system, a preparative electrophoresis platform that separates and extracts DNA fragments; gel cassettes that are used for the collection of DNA; and DNA control kits, which are used to test and QC Pippin systems. The company’s products are used in various applications, such as paired-end sequencing, preparation of adapter-ligated cDNAs of micro RNAs, bead template preparation, and ChIP...

500 Cummings Center

Suite 3150

Beverly, MA 01915

United States

Founded in 2005





Key Executives for Sage Science, Inc.

Chief Executive Officer and Director
Vice President for Corporate Operations
Director of Research
Chief Scientific Officer
Compensation as of Fiscal Year 2014.

Sage Science, Inc. Key Developments

Sage Science Introduces PippinHT

Sage Science introduced the PippinHT, a high-throughput version of the popular Pippin line of automated DNA size selection instruments for use with next-generation sequencers. The instrument will be particularly useful for scientists conducting large-scale genomic or transcriptomic studies. PippinHT incorporates the company's highly regarded sizing technology and increases throughput to 24 samples per run, compared to a maximum of five with Pippin Prep or BluePippin, and shortens run times by about 50 percent. The instrument offers an efficient, automated solution for scientists running sequencing labs, core facilities, and other laboratories producing large-scale sequencing data. PippinHT dramatically reduces NGS sample prep time and provides accurate, reproducible results while eliminating the risk of cross-contamination between samples. Independent studies of size selection methods have repeatedly demonstrated that the Pippin platform offers unparalleled reproducibility, accuracy, and sample recovery. Precise size selection is critical for optimizing sequencing efficiency, improving genome assemblies, and reducing project costs.

Sage Science Launches Unique Tool to Maximize Value of DNA and Protein Samples

Sage Science announced the release of its new SageELF technology for DNA and protein fractionation. This sample prep instrument will be especially useful for preserving precious samples and has applications in next-generation sequencing as well as bottom-up or top-down proteomics experiments. The SageELF generates 12 contiguous fractions from whole DNA or protein samples. For DNA or cDNA sequencing, that allows scientists to generate libraries with multiple insert sizes from the same sample, which has applications in genome sequencing, structural variant detection, and identification of rare splice variants. For protein studies, the ability to take many slices from a whole sample is useful for reducing sample complexity, enriching for rare proteins, and ensuring recovery of all proteins in the sample. The SageELF, short for Electrophoretic Lateral Fractionator, automatically electrophoreses samples and elutes whole DNA or proteins from the entire gel lane into 12 elution modules. Users simply load their sample, start the run, and pipette out the fractions later. Unlike in-gel digestion, in which some DNA fragments or peptides never leave the gel, the whole protein or DNA sample is electrophoresed into the elution modules.

Sage Science and Uniscience do Brasil Enter into Brazilian Distribution Agreement

Sage Science and Uniscience do Brasil announced a distribution agreement for Sage's Pippin DNA size selection product portfolio. Uniscience is the first distributor for Sage Science in the South American market. The Pippin DNA size selection system consists of an electrophoresis instrument and pre-cast, disposable gel cassettes. For collections of smaller fragments up to 1.5 kb, the Pippin Prep system facilitates the construction of next-generation sequencing libraries for paired-end sequencing, ChIP-seq, and preparing templates for emulsion PCR. If the collection of larger fractions is needed, the BluePippin system allows researchers to expand size selection to fragments up to 50 kb using pulsed-field electrophoresis. Pippin systems can be used as a replacement for manual gel purification for any application that requires, or can be improved by, this step.

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