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July 04, 2015 2:28 AM ET

Biotechnology

Company Overview of MediciNova Inc.

Company Overview

MediciNova, Inc., a biopharmaceutical company, focuses on acquiring and developing novel and small molecule therapeutics for the treatment of serious diseases with unmet medical needs for the United States market. Its product candidates include MN-166 (Ibudilast), an anti-inflammatory and neuroprotective agent, which has completed Phase II clinical trials for the treatment of neurological disorders; MN-221 (Bedoradrine), a ß2-adrenergic receptor agonist that has completed Phase IIb clinical trails for the treatment of acute exacerbations of asthma; MN-001 (Tipelukast), an orally bioavailable small molecule compound, which has completed a pre-clinical study for the treatment of nonalcoholic s...

4275 Executive Square

Suite 650

La Jolla, CA 92037

United States

Founded in 2000

10 Employees

Phone:

858-373-1500

Fax:

858-404-0048

Key Executives for MediciNova Inc.

Co-Founder, Chief Executive Officer, President and Executive Director
Age: 65
Total Annual Compensation: $504.8K
Head of Japanese Office and Vice President
Age: 47
Total Annual Compensation: $293.6K
Chief Medical Officer
Age: 49
Total Annual Compensation: $293.6K
Compensation as of Fiscal Year 2014.

MediciNova Inc. Key Developments

MediciNova Inc. Replaces Ernst & Young LLP with BDO USA, LLP as Independent Registered Public Accounting Firm for the Fiscal Year Ending December 31, 2015

The board of directors of MediciNova Inc. recently completed a competitive process to determine what audit firm would serve as the company’s independent registered public accounting firm for the fiscal year ending December 31, 2015. As a result of that process, on June 30, 2015, the company notified Ernst & Young LLP of its dismissal as the company’s independent registered public accounting firm effective as of that date. On June 30, 2015, the company selected BDO USA, LLP as its new independent registered public accounting firm, subject to completion of its standard client acceptance procedures.

MediciNova Inc. Announces the Completion of Enrollment in Clinical Trial of MN-166 (ibudilast) in Alcohol Dependence

MediciNova Inc. announced that the clinical trial of MN-166 (ibudilast) in alcohol dependence has completed enrollment of 24 subjects. This randomized, double-blind, placebo-controlled study has enrolled 24 non-treatment seeking individuals with either alcohol abuse or dependence in a UCLA research unit. Participants are randomly assigned to a 7-day treatment period involving repeat oral administration of either MN-166 escalated up to 100 mg/day or placebo. During the treatment period, participants will take the study medication, complete an IV alcohol challenge, and will take part in laboratory tests of alcohol craving as well as mood surveys and standard safety tests. Following a 7-10 day study break, trial participants are re-enrolled for another 7-day period wherein they cross over to the other treatment condition. The key study outcomes include safety, tolerability and preliminary efficacy as indicated by whether MN-166 reduces alcohol craving under controlled conditions.

MediciNova Inc. Announces Presentation of Interim Data from Clinical Trial of MN-166 in Alcohol Dependence at the 38th Annual RSA Scientific Meeting

MediciNova Inc. entitled 'A RESEARCH AGENDA ON THE CLINICAL NEUROSCIENCE OF ALCOHOLISM'. At the request of the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the sponsor of the study, the presentation included preliminary interim data from the first 22 subjects in the ongoing clinical trial of MN-166 (ibudilast) in alcohol dependence. Dr. Ray commented MN-166 (ibudilast) was very well tolerated and there were no drug-related drop outs or serious adverse events. The preliminary results indicate that ibudilast has beneficial effects on mood (p<0.05), decreased the daily measure of alcohol craving (p=0.05), and potentiated alcohol-induced sedation (p<0.05). This randomized, double-blind, placebo-controlled study will enroll 24 non-treatment seeking individuals with either alcohol abuse or dependence in a UCLA research unit. Participants will be randomly assigned to a 7-day treatment period involving repeat oral administration of either MN-166 escalated up to 100 mg/day or placebo. During the treatment period, participants will take the study medication, complete an IV alcohol challenge, and take part in laboratory tests of alcohol craving as well as mood surveys and standard safety tests. Following a 7-10 day study break, trial participants will re-enroll for another 7-day period wherein they will cross over to the other treatment condition. The key study outcomes include safety, tolerability and preliminary efficacy as indicated by whether MN-166 reduces alcohol craving under controlled conditions. MediciNova licensed MN-166 (ibudilast) from Kyorin Pharmaceutical Co. Ltd. for potential utility in RRMS. Intellectual property was additionally established or obtained by MediciNova in progressive MS and other neurological conditions. MN-166 (ibudilast) is a first-in-class, orally bioavailable, small molecule phosphodiesterase (PDE) -4 and -10 inhibitor and a macrophage migration inhibitory factor (MIF) inhibitor that suppresses pro-inflammatory cytokines and promotes neurotrophic factors. It attenuates activated glia cells, which play a major role in certain neurological conditions. Ibudilast's anti-neuroinflammatory and neuroprotective actions have been demonstrated in preclinical and clinical study results and provide the rationale for its therapeutic utility in neurodegenerative diseases (e.g., progressive MS and amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease), substance abuse/addiction and chronic neuropathic pain.

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