July 27, 2016 6:11 PM ET

Company Overview of Eastern Virginia Medical School

Company Overview

Eastern Virginia Medical School is an Educational Institution

358 Mowbray Arch Ste 305

Norfolk, VA 23507-2219

United States

Founded in 1964



Key Executives for Eastern Virginia Medical School

Age: 70
Compensation as of Fiscal Year 2016.

Eastern Virginia Medical School Key Developments

Researchers At the Ontario Institute for Cancer Research, University Health Network and Eastern Virginia Medical School Discover Protein Signatures for Accurate Non-Invasive Diagnosis of Aggressive Prostate Cancer

Researchers at the Ontario Institute for Cancer Research (OICR) and University Health Network (UHN), along with researchers at the Eastern Virginia Medical School, have created protein signatures that accurately diagnose prostate cancer and can distinguish between patients with aggressive versus non-aggressive disease using a simple urine sample. The findings could be developed into a non-invasive "liquid biopsy" that could provide a faster, cheaper and easier method to detect prostate cancer with fewer complications for patients. The findings were published on June 28, 2016 in the journal Nature Communications. Researchers performed an initial discovery screen on urine samples from men who were diagnosed with prostate cancer and those who were not to look for all proteins that might be different between them. They also screened for all proteins in the urine that might be different between patients with aggressive and non-aggressive disease. From these initial discoveries, they identified a subset of proteins unique to each grouping and developed two signatures: one that could be used to accurately indicate whether a patient has prostate cancer or not and a separate signature to indicate outcome. Current methods to diagnose prostate cancer usually include a combination of digital rectal exams, prostate specific antigen (PSA) tests and biopsy, all of which have drawbacks, including their invasiveness for patients, potential complications and false-positive results (tests finding evidence of cancer when none is there). Finding new ways to accurately diagnose prostate cancer is considered a priority for many research institutions, including OICR, because the result of these tests' shortcomings is in many cases over-diagnosis and over-treatment. There were three sites involved in the discovery and each brought their own unique expertise to the project. The Eastern Virginia Medical School developed clinical resources, while UHN researchers were generating large amounts of proteomic data and were developing new techniques to test proteins in blood. All of the proteomic and clinical data flowed to OICR where it was pieced together using computational biology, and where the proteins in the discovery screen were identified. The study has to date gone through development and initial validation and it is now ready for a large retrospective validation study, which the collaborators are now designing. After validation is successfully completed it would then move into clinical trials.

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