July 26, 2017 5:32 AM ET

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Company Overview of Cancer Research UK

Company Overview

Cancer Research UK is a charitable institution that supports and undertakes research on the biology and causes of cancer and develops anti-cancer drugs. The charity also provides general information about cancer and types of treatments and funds projects that help patients cope with the side effects of cancer and its treatment. The institute also operates an online portal CancerHelp UK that provides patient information. Cancer Research UK was incorporated in 2001 and is based in London, United Kingdom.

Angel Building

407 St. John Street

London,  EC1V 4AD

United Kingdom

Founded in 2001

Phone:

44 20 7242 0200

Fax:

44 20 3469 6400

Key Executives for Cancer Research UK

Chief Executive Officer and Chairman of the Executive Board
Chief Financial Officer
Compensation as of Fiscal Year 2017.

Cancer Research UK Key Developments

Cancer Research UK, Cancer Research Technology and Bicycle Therapeutics Collaborate to Trial New Therapy for Advanced Solid Tumours

Cancer Research UK, Cancer Research Technology (CRT), and Bicycle Therapeutics announced an agreement to trial a first-in-class drug for cancers of high unmet need. Cancer Research UK’s Centre for Drug Development (CDD) will sponsor and fund a Phase Ia and Phase Ib clinical trial for a drug called BT1718, a Bicycle Drug Conjugate® (BDC) being developed by Bicycle Therapeutics, in patients with advanced solid tumours. BT1718 targets Membrane Type 1 Matrix Metalloproteinase (MT1-MTP), which is highly expressed in many solid tumours, including triple negative breast cancer and non-small cell lung cancer. The trial will be co-managed by Cancer Research UK and Bicycle Therapeutics. Under the terms of the agreement, Bicycle retains the right to further advance the BT1718 programme, at which point an undisclosed payment split between cash and equity, success based milestones and royalty payments would be made to Cancer Research UK.

Cancer Research UK Enters into Joint Research Collaboration Agreement with Merck & Co and Verastem

Cancer Research UK has entered into joint research collaboration agreement with Merck & Co (US) and Verastem (US) to investigate the safety and efficacy of a combination immunotherapy to treat mesothelioma, non-small cell lung cancer (NSCLC), and pancreatic cancer. The Phase Ib/IIa trial will enrol 50-60 cancer patients and assess if Verastem's VS-6063 (defactinib), a focal adhesion kinase (FAK) inhibitor, can increase the effectiveness of Merck's PD-1 inhibitor Keytruda (pembrolizumab). The trial will be conducted at ECMC centres in Edinburgh-Dundee, Southampton, Glasgow, Leicester, and Belfast beginning some time between late 2016 and early 2017. It will be managed by Cancer Research UK and sponsored by the University of Glasgow and NHS Greater Glasgow and Clyde. Preliminary studies by scientists at the University of Edinburgh demonstrated that FAK inhibition can enhance the cancer immune response and potentially increase the efficacy of PD-1 checkpoint inhibition. The Combinations Alliance was forged to help bring drug developers and researchers together to investigate new drug combinations that could improve outcomes for cancer patients. This is the first such deal bringing together two industry partners to look at potential treatments for mesothelioma, NSCLC, and pancreatic cancer, which all have very low survival rates (less than half) within a year of diagnosis in England and Wales.

Cancer Research UK Presents at BIO Trinity 2016, Apr-27-2016 02:35 PM

Cancer Research UK Presents at BIO Trinity 2016, Apr-27-2016 02:35 PM. Venue: Novotel London West, 1 Shortlands, London W6 8DR, United Kingdom. Speakers: George Tzircotis, Snr Licensing Mgr, James Ritchie, Drug Dev Scientist.

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