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April 27, 2015 10:08 PM ET

Pharmaceuticals

Company Overview of Acetylon Pharmaceuticals, Inc.

Company Overview

Acetylon Pharmaceuticals, Inc. discovers and develops selective small molecule histone deacetylase inhibitors and other targeted drugs for the treatment of cancers, inflammatory, neurodegenerative, genetic, and infectious diseases. It has a strategic partnership with Celgene Corporation. The company was founded in 2008 and is based in Boston, Massachusetts.

70 Fargo Street

Suite 205

Boston, MA 02210

United States

Founded in 2008

Phone:

617-245-1300

Fax:

617-245-1301

Key Executives for Acetylon Pharmaceuticals, Inc.

Chief Executive Officer, President and Director
Age: 57
Co-Founder and Chairman of the Board
Age: 51
Scientific Founder, Director and Member of the Advisory Board
Age: 41
Scientific Founder and Member of the Advisory Board
Scientific Founder, Director and Member of the Advisory Board
Age: 63
Compensation as of Fiscal Year 2014.

Acetylon Pharmaceuticals, Inc. Key Developments

Acetylon Pharmaceuticals, Inc. Presents at Boston Biotech Conferences LLC's The East Meets West CEO conference, Jan-11-2015 01:40 PM

Acetylon Pharmaceuticals, Inc. Presents at Boston Biotech Conferences LLC's The East Meets West CEO conference, Jan-11-2015 01:40 PM. Venue: Four Seasons Hotel, 757 Market St, San Francisco, CA 94103, United States. Speakers: Walter C. Ogier, Chief Executive Officer, President and Director.

Acetylon Pharmaceuticals, Inc. Announces Phase 1b Combination Studies in Multiple Myeloma

Acetylon Pharmaceuticals, Inc. announced positive data from two ongoing Phase 1b combination clinical trials of ricolinostat, a selective HDAC6 inhibitor, for the treatment of relapsed or refractory multiple myeloma. In both studies, ricolinostat continues to demonstrate a favorable safety profile and substantial disease response rates. For ricolinostat in combination with lenalidomide (Revlimid®) and dexamethasone, the most common treatment emergent adverse events (AEs) were fatigue, upper respiratory infection, anemia, neutropenia, diarrhea, nausea, thrombocytopenia, muscle spasms, dizziness and rash as well as asymptomatic laboratory abnormalities. In combination with lenalidomide and dexamethasone, ricolinostat demonstrated an overall response rate of 64%, with of 80% of patients achieving minimal response or better, per modified International Myeloma Working Group (IMWG) criteria. The response rate in 21 relapsed, lenalidomide refractory patients was 50%, whereas the response rate in 13 non-refractory patients was 85%. These responses were durable, with patients remaining on therapy up to 23+ cycles of therapy. The most common AEs for ricolinostat in combination with bortezomib (Velcade®) and dexamethasone were diarrhea, increased creatinine, fatigue, anemia, nausea and thrombocytopenia that were predominantly grade 1-2. Diarrhea was the only AE that increased with higher ricolinostat exposure. Grade 3-4 thrombocytopenia was seen in 42% of patients. In combination with bortezomib and dexamethasone, ricolinostat demonstrated an overall response rate of 45% in disease evaluable patients and 30% in all patients, with 31% of all patients enrolled achieving minimal response or better (per modified IMWG criteria). The data were presented at the 56thAmerican Society of Hematology (ASH) Annual Meeting in San Francisco, California. Phase 1B Results of Ricolinostat (ACY-1215) Combination Therapy with Bortezomib and Dexamethasone in Patients with Relapsed or Relapsed and Refractory Multiple Myeloma (MM) (poster presentation, Abstract #4764): Of 43 patients, 3 achieved VGPR, 10 achieved PR, 2 achieved MR, 10 achieved SD and 4 had progressive disease, per modified IMWG criteria (Rajkumar, Blood 2011). 27 of 43 patients were refractory to bortezomib; within these patients, a 29 % overall response rate was achieved in response evaluable patients (4 of 14), and in 15% of all refractory patients entered on study. Treatment emergent adverse events (AEs) were predominantly grade 1-2. The most common AEs were diarrhea, thrombocytopenia, increased creatinine, fatigue, nausea, throat irritation, electrolyte abnormalities, cough, anemia, decreased appetite, peripheral neuropathy, peripheral edema, upper respiratory tract infection, dizziness, fever and vomiting. Thrombocytopenia and anemia were the most common grade 3 and 4 adverse events. Although there was no difference in the grade or frequency of overall AEs when ricolinostat dosing was increased to twice daily, diarrhea occurred earlier in the course of treatment and there was an increase in the frequency of serious adverse events.

Acetylon Pharmaceuticals, Inc. Presents at EBD Group's Biopharm America 2014 Conference, Sep-23-2014 02:00 PM

Acetylon Pharmaceuticals, Inc. Presents at EBD Group's Biopharm America 2014 Conference, Sep-23-2014 02:00 PM. Venue: Boston Marriott Copley Place, 110 Huntington Avenue, Boston, MA 02116, United States.

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