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April 24, 2015 9:19 PM ET

Biotechnology

Company Overview of Targazyme, Inc.

Company Overview

Targazyme, Inc., a biotechnology company, develops and commercializes products in the fields of cell and immunotherapy. The company’s products include TZ101 that attaches the sugar fructose to therapeutic cells, such as stem cells or immune cells to increase the ability of those cells to attach to selectins, which are proteins that are up regulated under conditions of inflammation, ischemia, and tissue damage. Its TZ101 is used for various applications for patients with cancer, such as cord blood transplantation for hematological malignancies, regulatory T cells and mesenchymal stem cells for graft versus host diseases, and natural killer cells for multiple myeloma and leukemia; Ischemic dis...

3200 County Road 104

Floresville, TX 78114

United States

Founded in 2005

Phone:

210-560-7689

Key Executives for Targazyme, Inc.

Co-Founder, Chairman and Chief Executive Officer
Co-Founder and Vice President of Manufacturing
Age: 58
Co-Founder and Vice President of Research
Chief Financial Officer
Senior Vice President of Regulatory Affairs & Quality Assurance
Age: 71
Compensation as of Fiscal Year 2014.

Targazyme, Inc. Key Developments

Targazyme, Inc. Receives U.S. Food and Drug Administration IND Clearance for Phase I/II Study of TZ101-Treated Regulatory T Cells to Prevent Graft

Targazyme, Inc. announced that the U.S. Food and Drug Administration (FDA) has granted IND Clearance to M.D. Anderson Cancer Center to start enrolling patients in a Phase I/II clinical study to evaluate the safety and efficacy of TZ101-fucosylated regulatory T cells (Tregs) in preventing and reducing the severity and incidence of graft vs. host disease (GVHD) in patients eligible for hematologic stem cell transplant. GVHD is a serious, life-threating complication of stem cell transplantation, affecting over 60% of all patients undergoing allogeneic stem cell transplantation. This clinical study hopefully will affirm Targazyme's novel treatment approach. TZ101 could potentially transform hematopoietic stem cell transplantation by reducing patient morbidity and mortality from GVHD, which occurs in a high percentage of these patients and is very difficult to manage clinically. If the efficacy of TZ101-treated Tregs is demonstrated in GVHD, then the company expects the treatment to be useful in a number of autoimmune diseases such as rheumatoid arthritis, multiple sclerosis and others.

Targazyme Inc. Receives Orphan Drug Designation to TZ101 for Use with Regulatory T Cells to Prevent & Reduce the Severity of Graft Versus Host Disease in Patients Eligible for Hematologic Stem Cell Transplantation

Targazyme Inc. announced that the U.S. Food and Drug Administration (FDA) has granted Orphan Drug designation to TZ101 to prevent and reduce the severity and incidence of graft vs. host disease (GVHD) in patients eligible for hematologic stem cell transplant. GVHD is a serious, life-threating complication of stem cell transplantation. Orphan drug status confirms the importance of Targazyme's novel treatment approach to prevent and reduce the incidence and severity of GVHD in patients with blood cancers where stem cell transplant is prescribed. TZ101 could potentially transform hematopoietic stem cell transplantation by reducing patient morbidity and mortality from GVHD, which occurs in a large percentage of these patients and is very difficult to manage clinically.

Targazyme, Inc. Presents at 13th Annual BIO Investor Forum, Oct-07-2014

Targazyme, Inc. Presents at 13th Annual BIO Investor Forum, Oct-07-2014 . Venue: The Palace Hotel, San Francisco, CA 94105, United States.

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