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August 03, 2015 3:23 PM ET

Healthcare Equipment and Supplies

Company Overview of Tissue Regeneration Systems Inc.

Company Overview

Tissue Regeneration Systems Inc., a medical device company, is engaged in commercializing a skeletal reconstruction and bone regeneration technology platform for clinical applications in the United States. It serves craniomaxillofacial surgery, orthopedic surgery, spine fusion surgery, and bone growth factor delivery markets. The company was incorporated in 2005 and is based in Plymouth, Michigan with an additional office in Kirkland, Washington.

46701 Commerce Center Drive

Plymouth, MI 48170

United States

Founded in 2005



Key Executives for Tissue Regeneration Systems Inc.

Chief Executive Officer and President
Co-Founder and Director
Founder and Director
Compensation as of Fiscal Year 2015.

Tissue Regeneration Systems Inc. Key Developments

DePuy Synthes Products and Johnson & Johnson Innovation Partners with Tissue Regeneration Systems

DePuy Synthes Products, LLC and Johnson & Johnson Innovation LLC (JJI) have formed a strategic partnership with Tissue Regeneration Systems, Inc. to develop patient-specific, resorbable implants for large bone segmental defect treatment in trauma and orthopedic oncology. The partnership also includes potential future development opportunities in a range of additional applications within DePuy's areas of strategic interest.

Tissue Regeneration Systems, Inc. Receives 510K Approval from U.S. Food and Drug Administration for Cranial Bone Void Filler Product

Tissue Regeneration Systems, Inc. announced that it has received 510K approval from the U.S. Food and Drug Administration for its Cranial Bone Void Filler product, indicated for use in the repair of neurosurgical burr holes. This is first of a family of craniomaxillofacial surgery products being developed by the company that incorporate the company's novel skeletal reconstruction and bone regeneration technology platform. The 510K approval process required the company to meet a high standard of pre-clinical testing and successfully pass a rigorous review by the FDA. Applying a technology platform created at the Universities of Michigan and Wisconsin, the company is developing advanced skeletal reconstruction implants with attributes. They are bioresorbable over time, fully replacing themselves with natural bone. Although their micro-architecture is porous to facilitate bone integration, they can bear load and they are strong enough to support function without need for reinforcement with metal plates. This structural integrity allows them to be used as an alternative to bone harvested from the patient for complex skeletal reconstruction. Using input from patient CT scans, their geometry can be custom constructed. Finally, they are integrated with a proprietary, osteoconductive coating that serves as an excellent substrate for adhesion and local, controlled release of growth factors to enhance bone regeneration.

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