Oklahoma Medical Research Foundation is a nonprofit biomedical research foundation that focuses on drug development for human disease, focusing on such critical research areas as heart disease, cancer, lupus, and Alzheimer’s disease. The institution was founded in 1946 and is based in Oklahoma City, Oklahoma.
825 N.E. 13th Street
Oklahoma City, OK 73104
Founded in 1946
OMRF and Biogen Enter Autoimmune Disease Collaboration
Oct 22 15
OMRF and Biogen have formed a research collaboration. Under the new agreement, Biogen researchers will work with Kathy Sivils, a member of OMRF's Arthritis and Clinical Immunology Research Program, in an effort to develop biomarkers that could predict if patients suffering from the autoimmune disease Sjogren's syndrome might benefit from new approaches of treatment that are being developed by Biogen. The project is a part of a personalised medicine initiative where advance testing is utilized to identify the patients most likely to respond to specific treatments. Using resources and data developed in Sivils' lab at OMRF, the company hopes identify patients likely to respond to a particular course of treatment for Sjogren's. In Sjogren's syndrome, the body's immune system mistakenly attacks its moisture-producing glands, resulting in dry eyes, dry mouth, fatigue and joint pain. According to the Sjogren's Syndrome Foundation, the illness affects an estimated 4 million Americans. The disease's symptoms often mimic those of other autoimmune diseases like lupus, rheumatoid arthritis, fibromyalgia or multiple sclerosis, making it difficult to diagnose. Drops and preparations for dry eyes and mouth can help temporarily, but immunosuppressive medications may be necessary to manage internal organ issues or severe flares. In the lab, Sivils and her colleague Darise Farris, Ph.D., are looking for biomarkers--substances that indicate the presence of disease--in Sjogren's patients that might identify how well each person will respond to a specific drug. Sivils and Biogen researchers are analyzing patient samples to try to pinpoint which biomarkers make them good candidates for specific medications before they actually begin treatment. Sivils was the first researcher to launch a large-scale, genome-wide association study of patients with Sjogren's syndrome. In 2013, led an international coalition of researchers that identified six new genes related to the illness. At OMRF, Sivils has built a unique collection of biological samples gathered from patients in the foundation's Sjogren's research clinic. The samples give Sivils and her collaborators access to biological materials that are essential to developing new ways to diagnose and treat the disease. Sivils hopes the collaboration with Biogen will create a companion diagnostic that will help physicians deliver the most effective treatment to individual patients.
Oklahoma Medical Research Foundation Appoints Manu Nair as Vice President of Technology Ventures
Jun 24 14
Oklahoma Medical Research Foundation announced that Manu Nair as appointed as vice president of technology ventures. Nair returns to the OMRF after five years as a licensing manager at the Mayo Clinic in Rochester, Minn.