Company Overview of NGM Biopharmaceuticals, Inc.
NGM Biopharmaceuticals, Inc., a biopharmaceutical company, discovers and develops transformational biologics for the treatment of cardio-metabolic diseases, hepatic diseases, and cancers. It offers NGM282, a phase 2 clinical development product that is used for the treatment of gastric bypass surgery on metabolic and bile acid-related diseases. The company also develops novel drug candidates for the treatment of Type 2 diabetes and obesity. In addition, it offers various drug discovery programs that include enteroendocrine cells, beta-cell regeneration, and intestinal microbiome programs. The company has strategic partnerships with MedImmune/AstraZeneca, Daiichi Sankyo, and JDRF. NGM Biophar...
630 Gateway Boulevard
South San Francisco, CA 94080-7014
Founded in 2007
Key Executives for NGM Biopharmaceuticals, Inc.
Chief Executive Officer and Director
Founder, Chief Scientific Officer and Director
Chief Medical Officer and Vice President
Compensation as of Fiscal Year 2014.
NGM Biopharmaceuticals, Inc. Key Developments
NGM Biopharmaceuticals, Inc. Announces Positive Phase 2 Clinical Data in Primary Biliary Cirrhosis Patients for NGM282
Mar 24 15
NGM Biopharmaceuticals, Inc. reported positive results from a Phase 2 trial of NGM282 in patients with primary biliary cirrhosis (PBC). NGM282, an engineered protein variant of the human hormone FGF19, demonstrated statistically significant, dose-dependent and clinically meaningful reductions in alkaline phosphatase (ALP), a primary indicator of disease activity, as well as substantial reductions in 7-Hydroxy-4-cholesten-3-one (C4), a marker of bile acid synthesis. These data suggested that NGM282 is a potent regulator of bile acid synthesis. The study was a double blind, placebo-controlled trial in 45 patients randomized 1:1:1 to daily injections of 0.3 mg or 3 mg doses of NGM282 or placebo. Study subjects had a confirmed PBC diagnosis with an inadequate response to ursodeoxycholic acid (UDCA), the current standard of care, defined as an elevated ALP level greater than 1.67 times the upper limit of normal while on therapeutic doses of UDCA for at least 12 months. All subjects continued with UDCA treatment during the study. Patients with pruritus, hyperlipidemia and other comorbidities commonly seen in PBC were allowed to enroll in the study. Data from the trial demonstrated a statistically significant and clinically meaningful percentage reduction in ALP from baseline to day 28 in both NGM282 treatment arms (0.3 mg = -15.8%, p-value = 0.009; 3 mg = -19.2%, p-value = 0.003). Significant reductions of other key markers of liver injury, such as ALT and AST, were also observed for both NGM282 treatment groups. Importantly, NGM282 did not exacerbate pruritus, which is a symptom frequently experienced by many PBC patients that substantially impacts quality of life. More than 50% of study subjects had pruritus at baseline, which was balanced across the three groups. All subjects with pruritus at baseline treated with 3 mg of NGM282 had either an improvement or no worsening of their pruritus during the study. Two subjects without pruritus at baseline, one in each treatment arm, presented with mild, transient pruritus during the study period. However, the overall study assessment demonstrated that there was no significant evidence of drug-induced pruritus in any study arm. NGM282 had a favorable safety and tolerability profile with no identified safety signals. Most adverse events were mild, with a single serious adverse event during the study period that was deemed unrelated to treatment by the investigator. The most common adverse events were mild headache and mild lower gastrointestinal (GI) symptoms (predominantly diarrhea and loose stools). The lower GI symptoms were observed in 21% of the 0.3 mg and 43% of the 3 mg cohorts, compared to 13% of the placebo group. Mild injection site reactions (predominantly erythema or redness) were also observed more frequently with NGM282. There was no evidence of an immunogenic response to NGM282 during or after the treatment period. All lipid parameters and triglycerides remained stable during the treatment period.
NGM Biopharmaceuticals Announces Management Appointments
Mar 2 15
NGM Biopharmaceuticals, Inc. announced that Jeff Jonker has been named President and David Woodhouse, Ph.D., has joined the company as Chief Financial Officer, effective immediately. Prior to joining NGM, Mr. Jonker was the Senior Vice President, Corporate and Business Development at Theravance Biopharma and Theravance, Inc. He previously served as the Chief Business Officer of Satori Pharmaceuticals and the Vice President of Business Development and Corporate Strategy for Gloucester Pharmaceuticals, prior to its acquisition by Celgene. Dr. Woodhouse joins NGM from Goldman Sachs, where he was Managing Director and Co-Head of U.S. Biotechnology Investment Banking. As a member of Goldman's healthcare investment banking group for nearly 13 years in the New York and San Francisco offices, Dr. Woodhouse's responsibilities included corporate finance and mergers and acquisitions (M&A) advice for the biotechnology, specialty pharma and diagnostics industries.
NGM and Merck Announce Broad Strategic Collaboration to Discover, Develop and Commercialize Novel Biologic Therapeutics
Feb 23 15
NGM Biopharmaceuticals, Inc. and Merck announced they have entered into a multi-year collaboration to research, discover, develop and commercialize novel biologic therapies across a wide range of therapeutic areas. This agreement will become effective upon the expiration of the waiting period under the Hart-Scott-Rodino Antitrust Improvements Act. The collaboration includes multiple drug candidates currently in preclinical development at NGM, including NP201, which is being evaluated for the treatment of diabetes, obesity and nonalcoholic steatohepatitis (NASH). NGM will lead the research and development of the existing preclinical candidates and have the autonomy to identify and pursue other discovery stage programs at its discretion. Merck will have the option to license all resulting NGM programs following human proof of concept trials. If Merck exercises this option, Merck will lead global product development and commercialization for the resulting products, if approved. Under the terms of the agreement, Merck will make an upfront payment to NGM of $94 million and will purchase a 15% equity stake in NGM for $106 million at a price per share that represents a 20% premium to NGM’s most recent financing. Merck will commit up to $250 million to fund all of NGM’s efforts under the initial five-year term of the collaboration, with the potential for additional funding if certain conditions are met. Prior to Merck initiating a Phase 3 study for a licensed program, NGM may elect to either receive milestone and royalty payments or, in certain cases, to co-fund development and participate in a global cost and revenue share arrangement of up to 50%. The agreement also provides NGM with the option to participate in the co-promotion of any co-funded program in the United States. Merck will have the option to extend the research agreement for two additional two-year terms.
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