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November 25, 2015 8:13 PM ET

Diversified Consumer Services

Company Overview of The University of Texas M. D. Anderson Cancer Center

Company Overview

The University of Texas M. D. Anderson Cancer Center is an educational institution that offers undergraduate and research programs to physicians, biomedical scientists, and other health-care professionals. The departments include behavioral medicine, biochemistry and molecular biology, cancer biology program, cancer genomics core laboratory, molecular and cellular oncology, molecular genetics, molecular hematology and therapy, molecular therapeutics, and molecular pathology. The University of Texas M. D. Anderson Cancer Center was founded in 1941 as Texas State Cancer Hospital and the Division of Cancer Research and changed its name to M. D. Anderson Hospital for Cancer Research of The Unive...

1515 Holcombe Boulevard

Houston, TX 77030

United States

Founded in 1989



Key Executives for The University of Texas M. D. Anderson Cancer Center

Age: 60
Executive Vice President and Physician-In-Chief
Chairman of Department of Health Disparities Research
Vice President and Head of the Division of Pharmacy
Compensation as of Fiscal Year 2015.

The University of Texas M. D. Anderson Cancer Center Key Developments

Cytomx Therapeutics and the University of Texas Md Anderson Cancer Center Enter into Strategic Collaboration for Probody-Enabled CAR-NK Cell Therapies

CytomX Therapeutics entered into a collaboration with The University of Texas MD Anderson Cancer Center to research Probody-enabled chimeric antigen receptor natural killer (CAR-NK) cell therapies, to be known as ProCAR-NK cell therapies. MD Anderson will leverage its expertise in developing allogeneic umbilical cord blood and peripheral blood derived NK-cell therapies and combine it with CytomX's Probody technology to address new targets for this novel modality in cancer immunotherapy. Designed for more precise binding to tumors and reduced binding to healthy tissue, ProCAR-NK cell therapies will be created against targets for which safety and toxicity have traditionally been limiting factors for CAR cell therapies. Under the collaboration, CytomX and MD Anderson will develop ProCAR-NK cell therapies against multiple targets, and CytomX will have the option to license therapeutics that demonstrate preclinical proof of concept for clinical and commercial development. From MD Anderson, the collaboration will be led by Katy Rezvani, M.D., Ph.D., professor, department of Stem Cell Transplantation and Cellular Therapy; and Elizabeth Shpall, M.D., professor, department of Stem Cell Transplantation and Cellular Therapy. Rezvani has conducted more than a decade of research in NK-cell therapies. Therapeutics developed with CytomX's Probody platform have a mask linked to the antibody's antigen-binding site designed to avoid the binding of antigens on healthy tissue. The mask is cleaved by proteases found in the tumor microenvironment, allowing Probody therapeutic to selectively bind to tumor cells. This binding selectivity allows CytomX to potentially expand the therapeutic window for both existing and new antigen targets. CytomX's pipeline of wholly owned and partnered programs includes development-stage Probody cancer immunotherapies, Probody drug conjugates and Probody bispecifics. NK cells are cytotoxic lymphocytes that comprise a central component of the innate immune system. When these cells are engineered to express CARs that target proteins found on cancer cells, they demonstrate powerful anti-tumor responses. The resulting therapeutic class has potential advantages over CAR-T cells, including simpler manufacturing.

The University of Texas MD Anderson Cancer Center, Cayman Chemical and Fannin Innovation Studio Form Therapeutics Company

The University of Texas MD Anderson Cancer Center, Cayman Chemical and Fannin Innovation Studio have formed ACF Pharmaceuticals, LLC. The pre-clinical therapeutics company is dedicated to discovering and developing novel small molecule inhibitors for the treatment of a variety of inflammation-induced cancers, including melanoma and colon and pancreatic cancer. Chronic inflammation has long been associated with cancer development and the cyclooxygenase pathway (COX) involved in promoting it. The COX enzymes are popular therapeutic targets; however, COX inhibitors have a variety of unwanted side effects that limit their use. ACF is working to develop two different approaches that will target this inflammatory pathway to block cancer progression and enhance the anti-tumor immune response. Under the terms of a parallel joint development agreement, Cayman's drug discovery program will focus on developing novel agents including the design, optimization, synthesis and initial screening for therapeutic applications in cancer, fibrosis, inflammation and pain. MD Anderson will use existing and newly developed models to evaluate candidate molecules, working with Cayman and Fannin to identify and advance the lead development. Fannin, a Houston-based, early-stage life science commercialization firm, is providing early-stage funding and will manage ACF, providing intellectual property strategy, capitalization and grant strategy, and business development.

The University of Texas M. D. Anderson Cancer Center and Cellectis Announce A Broad Preclinical and Clinical Strategic Alliance in Cancer Immunotherapy

Cellectis and The University of Texas MD Anderson Cancer Center have entered into a research and development alliance aimed at bringing novel cellular immunotherapies to patients suffering from different types of liquid tumors. The alliance is aimed at developing novel cancer immunotherapies based on Cellectis allogeneic chimeric antigen receptor (CAR) platform. MD Anderson Cancer Center's leukemia and myeloma teams will work with Cellectis to bring better treatments to patients suffering from cancers with high unmet needs, particularly multiple myeloma (MM), acute lymphocytic leukemia (ALL), T-cell acute lymphocytic leukemia (ALL) and blastic plasmacytoid dendritic cell neoplasm (BPDCN). The alliance will build on MD Anderson's outstanding translational and preclinical and clinical teams in leukemia and myeloma, coupled with Cellectis allogeneic CAR T-cell therapy approach and manufacturing capabilities, to pursue the development of Cellectis candidate products UCARTCS1, UCART22, UCART38 in T-cell ALL and UCART123 in a rare non curable disease BPDCN. Cellectis has built an allogeneic CAR T-cell approach based on proprietary gene editing technologies, aimed at developing off-the-shelf cellular therapies for cancer treatment.

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