Company Overview of Heptares Therapeutics Ltd.
Heptares Therapeutics Ltd. operates as a drug discovery company. It designs and develops drugs to tackle diseases involving the nervous system and metabolism. The company was founded in 2007 and is based in Welwyn Garden City, United Kingdom.
Welwyn Garden City, AL7 3AX
Founded in 2007
Key Executives for Heptares Therapeutics Ltd.
President of USA Operations
Chief Medical Officer and Vice President of Development
Compensation as of Fiscal Year 2014.
Heptares Therapeutics Ltd. Key Developments
Heptares Technology Enables Breakthrough in Drug Discovery Collaboration with AstraZeneca
Jan 22 15
Heptares Therapeutics announced significant progress in its drug discovery collaboration with AstraZeneca. Using Heptares proprietary StaR technology, the first-ever stable version of Protease-Activated Receptor-2 (PAR2) in a therapeutically relevant form has been generated, from which its X-ray structure has been solved. PAR2 is a G protein-coupled receptor (GPCR) that is a well-validated target for multiple indications in pain and inflammatory diseases. Working with scientists at AstraZeneca, the PAR2 StaR protein was used to screen compound libraries resulting in the identification of a hit series of small molecules that bind and block its activity. The X-ray structure information, which yields new details about the unusual binding pocket of PAR2, is now being used at AstraZeneca to further optimize the hit molecules; to increase their binding affinity, potency as antagonists as well as improving their drug-like properties (e.g. oral bioavailability and stability).
Heptares Therapeutics Ltd. Presents at Boston Biotech Conferences LLC's The East Meets West CEO conference, Jan-10-2015 through Jan-11-2015
Dec 3 14
Heptares Therapeutics Ltd. Presents at Boston Biotech Conferences LLC's The East Meets West CEO conference, Jan-10-2015 through Jan-11-2015. Venue: Four Seasons Hotel, 757 Market St, San Francisco, CA 94103. Presentation Date & Speakers: Jan-10-2015, Daniel Grau, President of USA Operations. Jan-11-2015, Malcolm Weir, Chief Executive Officer.
Heptares Therapeutics Ltd. Presents at EBD Group's Biopharm America 2014 Conference, Sep-22-2014 through Sep-24-2014
Sep 10 14
Heptares Therapeutics Ltd. Presents at EBD Group's Biopharm America 2014 Conference, Sep-22-2014 through Sep-24-2014. Venue: Boston Marriott Copley Place, 110 Huntington Avenue, Boston, MA 02116, United States. Presentation Date & Speakers: Sep-22-2014, Daniel Grau, President of USA Operations. Sep-24-2014.
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