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June 03, 2015 9:46 AM ET


Company Overview of PNP Therapeutics, Inc.

Company Overview

PNP Therapeutics, Inc., a biopharmaceutical company, develops a platform technology and proprietary products for the treatment of cancer based on the selective expression of E. coli purine nucleoside phosphorylase in tumor cells. The company is based in Birmingham, Alabama.

4363 1st Avenue North

Birmingham, AL 35222

United States





Key Executives for PNP Therapeutics, Inc.

Chief Executive Officer and Director
Co-Founder, President, Director and Member of Scientific Advisory Board
Co-Founder, Vice President, Secretary, Director and Member of Scientific Advisory Board
Compensation as of Fiscal Year 2014.

PNP Therapeutics, Inc. Key Developments

PNP Therapeutics Provides Progress Update on Cancer-Fighting Technology in Phase I Clinical Trial

PNP Therapeutics, Inc. announced that it has found an approach that has abolished otherwise unmanageable human cancers in preclinical rodent studies. PNP confirmed that it has completed the first three cohorts of its Phase I clinical trial and is now recruiting for the fourth cohort. The company is looking ahead to Phase II trials and seeking an appropriate partner in the pharmaceutical industry. In Phase I clinical trials, patient safety and efficacy are evaluated. In PNP's Phase I trial, an adenoviral vector is used to deliver E. coli PNP to head and neck tumors followed by intravenous administration of the prodrug fludarabine. The therapy was well-tolerated in the first nine patients, and doctors have detected efficacy. The technology -- based on the notion that solid tumors can be programmed to generate their own very potent chemotherapy -- was discovered by Parker and Eric Sorscher, M.D., professor of Medicine of Hematology/Oncology at UAB. Selectivity of the therapeutic approach is achieved by producing an enzyme called E. coli purine nucleoside phosphorylase (PNP) directly within tumor cells and using the enzyme to generate novel chemotherapy in the tumor mass itself. The resulting compound works by a unique mechanism of action unlike any drug currently used in the treatment of cancer, and it destroys replicating and non replicating malignant cells while minimizing damage to surrounding, healthy cells.

PNP Therapeutics, Inc. Announces Board Appointments

PNP Therapeutics, Inc. announced that Dr. J. Claude Bennett and Mr. James F. Fuqua have joined its Board of Directors. In 1997, Dr. Bennett was designated by the University Board of Trustees as Distinguished University Professor Emeritus. He served as President and Chief Operating Officer of BioCryst Pharmaceuticals, Inc. from 1997-2009. Prior to assuming this position, he served as President of the University of Alabama at Birmingham (UAB). His work has appeared in more than 200 scholarly journals and publications. Mr. Fuqua has demonstrated top level performance in multi-national and small corporate strategies, business development, senior sales management and health science organizations. He is currently Senior Consultant for The Center for Leadership Studies/Performance Impact, Inc. Prior to that he was Vice President, Strategic and Business Development for CE Outcomes, LLC and held several senior management positions with Merck and Co. from 1979-2010.

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