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May 25, 2015 12:19 AM ET

Healthcare Equipment and Supplies

Company Overview of Tryton Medical, Inc.

Company Overview

Tryton Medical, Inc. manufactures and sells side branch stent systems for the treatment of coronary bifurcation lesions patients. It offers its products through a network of distributors internationally, as well as provides for investigational needs in the United States. The company was founded in 2003 and is based in Durham, North Carolina.

1000 Park Forty Plaza

Suite 325

Durham, NC 27713

United States

Founded in 2003





Key Executives for Tryton Medical, Inc.

Chief Executive Officer, President and Director
Age: 45
Founder and Director
Chief Financial Officer
Age: 46
Chief Operating Officer
Vice President of Regulatory and Quality
Compensation as of Fiscal Year 2014.

Tryton Medical, Inc. Key Developments

Tryton Medical, Inc. Receives CE-Mark for the Left Main Indication

Tryton Medical, Inc. announced that it has received CE Mark for the treatment of Left Main Coronary artery disease. With this approval, Tryton Medical becomes the first company to earn a CE Mark for this indication. Left main disease, an accumulation of plaque that narrows the base of the coronary tree, is a persistent challenge in interventional cardiology, as more than 75% of left main lesions are bifurcations. There are approximately 200,000 cardiac surgeries performed in left main annually.

Tryton Medical, Inc. Announces First Results from Pivotal Study of the Tryton Side Branch Stent Presented at TCT 2013 Annual Meeting in Late Breaking Clinical Trial Session

Tryton Medical, Inc. announced the first results from the Tryton Side Branch Stent Pivotal IDE trial were presented during a Late Breaking Clinical Trial session at the 25(th) annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. The Tryton Pivotal IDE trial is an international, randomized study that compares a Tryton Side Branch Stent to conventional provisional treatment (balloon angioplasty) in the side branch, with both study groups receiving a standard drug eluting stent (DES) in the main vessel. The study, which is the first randomized FDA IDE pivotal clinical trial to evaluate a dedicated bifurcation stent, enrolled 704 patients at 67 centers in North America and 11 countries throughout Europe and Israel. It is larger coronary bifurcation study ever conducted and the first study to employ core lab angiographic (3D and planar) and IVUS analysis. Key findings from the study include: Both the Tryton strategy and the provisional strategy appeared to be safe, with rare clinical post procedure myocardial infarctions, low rates of stent thrombosis, and no cardiac death. Both study arms had low 9-month clinically driven target vessel revascularization, or TVR (Tryton 4.7%; Provisional 3.6%). Tryton, compared to the provisional arm of the study, did not meet the non-inferiority clinical endpoint of target vessel failure (TVF)1, driven in large part by peri-procedural CK-MB elevations (Tryton 17.4%; Provisional 12.8%). 60% of the side branch vessels treated were smaller than the intended study population of side branch vessels of 2.25 mm diameter or greater by QCA. Tryton, compared to the provisional arm of the study, demonstrated superiority in reducing percent diameter side branch stenosis (Tryton 31.6%; Provisional 38.6%; p=.002), the powered secondary endpoint. Post hoc subgroup analysis of the intended study population demonstrated Tryton out performed the provisional arm of the study in TVF (Tryton 11.3%, Provisional 15.6%) as well as reduced percent diameter stenosis (Tryton 30.4%; Provisional 40.6%; p=.004).

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