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March 27, 2015 5:13 AM ET


Company Overview of ProFibrix, BV.

Company Overview

ProFibrix, BV. develops and markets products for hemostasis and regenerative medicine markets. It offers Fibrocaps, a dry powder topical fibrin sealant based on a mixture of fibrinogen and thrombin, which helps to stop bleeding during surgery and after trauma injury. The company offers its products based on human fibrinogen, a natural blood protein for blood clotting and tissue healing. ProFibrix, BV. was founded in 2004 and is based in Leiden, the Netherlands with a subsidiary and office in Seattle, Washington. It has a manufacturing site in the United Kingdom. As of August 5, 2013, ProFibrix, BV. operates as a subsidiary of The Medicines Company.

Darwinweg 24

Leiden,  2333 CR


Founded in 2004


31 88 730 8301


31 88 730 8383

Key Executives for ProFibrix, BV.

Chief Executive Officer, President and Chief Operating Officer
Age: 57
Vice President of Finance
President of Profibrix Inc
Chief Medical Officer
Chief Business Officer
Compensation as of Fiscal Year 2014.

ProFibrix, BV. Key Developments

ProFibrix B.V. Completes Enrolment of its Pivotal Phase III Clinical Trial with Fibrocaps

ProFibrix B.V. announced that the company has completed enrolment of its pivotal Phase III clinical trial with Fibrocaps (FINISH-3) on schedule. FINISH-3 is a multicenter, randomized, single-blind, controlled Phase III trial of Fibrocaps in surgical patients with mild to moderate surgical bleeding. Participating surgeons enrolled a total of 718 patients in only 10 months. The main objectives of the study are to demonstrate superior efficacy of Fibrocaps vs. gelatin sponge within four surgical indications, and to confirm the overall safety results from the Phase II Fibrocaps trials. Final study results are expected to be announced in the summer of 2013. Fibrocaps is a mixture of two essential blood clotting proteins, fibrinogen and thrombin, formulated as a unique dry powder topical fibrin sealant, which is being developed to stop bleeding during or after surgery. Fibrocaps is clearly differentiated from existing liquid fibrin sealants and hemostats: it is ready for immediate use, and is stable at room temperature.

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