National Cancer Institute, SWOG Cancer Research, Friends of Cancer Research, the Foundation for the National Institutes of Health and Foundation Medicine Announces Initiation of the Lung Cancer Master Protocol (Lung-MAP) Trial
Jun 16 14
A unique public-private collaboration among the National Cancer Institute, part of the National Institutes of Health, SWOG Cancer Research, Friends of Cancer Research, the Foundation for the National Institutes of Health (FNIH), five pharmaceutical companies (Amgen, Genentech, Pfizer, AstraZeneca, and AstraZeneca's global biologics R&D arm, MedImmune), and Foundation Medicine announced the initiation of the Lung Cancer Master Protocol (Lung-MAP) trial. Lung-MAP is a multi-drug, multi-arm, biomarker-driven clinical trial for patients with advanced squamous cell lung cancer. Squamous cell carcinoma represents about a quarter of all lung cancer diagnoses, but there are currently few treatment options beyond surgery for the disease. The trial will use genomic profiling to match patients to one of several different investigational treatments that are designed to target the genomic alterations found to be driving the growth of their cancer. This innovative approach to clinical testing should both improve access to promising drugs for patients and ease the significant recruitment and infrastructure burdens on researchers involved in traditional clinical trials. The trial will initially test five experimental drugs-four targeted therapies and an anti-PD-L1 immunotherapy. It is anticipated that between 500 and 1000 patients will be screened per year for over 200 cancer-related genes for genomic alterations. The results of this test will be used to assign each patient to the trial arm that is best matched to their tumor's genomic profile.
The Lupus Foundation of America Partners with Foundation for the National Institutes of Health to Support a New Five-Year Initiative
Feb 4 14
The Lupus Foundation of America will partner with the Foundation for the National Institutes of Health to support a new five-year initiative that will accelerate the ability to develop new medicines for lupus and other diverse and complex diseases. Lupus is included among four diseases that will be the focus of the new Accelerating Medicines Partnership (AMP). The project is a $235 million collaborative effort by government, academia, industry and nonprofit health organizations that will support research to more fully understand the underlying causes of specific diseases and identify and validate the right biologic targets to pursue for possible drug therapies. The goals of AMP are to increase the number of new diagnostic tests and treatments for specific diseases, and to reduce the time and expense required to bring new therapies into clinical use. The four diseases selected for the initial project are Alzheimer's disease, type 2 diabetes, rheumatoid arthritis (RA) and lupus. The project allocates $41.6 million specifically for research on the autoimmune diseases RA and lupus.