Company Overview of Lycera Corp.
Lycera Corp., a biopharmaceutical company, develops oral immune modulators for the treatment of patients with autoimmune diseases and cancer. Its product pipeline includes LYC-30937, an ATPase modulator for the treatment of inflammatory bowel disease; oral RORgamma agonists for diverse applications in immune-oncology; and Rho kinase inhibitors, histone deacetylase 6 inhibitors, RORgt antagonists, and collaboration targets. Lycera Corp. was founded in 2006 and is headquartered in Ann Arbor, Michigan.
2800 Plymouth Road
Ann Arbor, MI 48109
Founded in 2006
Key Executives for Lycera Corp.
Chief Executive Officer, President and Director
Senior Vice President of Biology
Compensation as of Fiscal Year 2016.
Lycera Corp. Key Developments
Lycera Announces Initiation of Phase 2 Clinical Trial of LYC-30937-EC in Patients with Ulcerative Colitis
Aug 22 16
Lycera Corp. announced the initiation of a Phase 2 clinical trial of the company's lead clinical-stage candidate, LYC-30937-Enteric Coated, in patients with ulcerative colitis (UC). The UPSTART study (Ulcerative Colitis Phase 2 Study To Assess Remission by Treatment with LYC-30937-EC) is expected to enroll up to 120 patients and is designed to assess the efficacy and safety of LYC-30937-EC given orally once daily in subjects with active ulcerative colitis. Ulcerative colitis (UC) is a chronic, often debilitating inflammatory bowel disease of the large intestine that is estimated to affect as many as 700,000 individuals in the United States. Current systemic therapies for the treatment of UC result in long-term clinical remission rates of below 50% and often lead to side effects, including pronounced immune suppression. Up to one-third or more of patients may require surgery, in which a portion of the colon is removed (colectomy), at some point in their lifetime. In Lycera's randomized, double-blind, placebo-controlled parallel group Phase 2 study, patients will be randomized on a 1:1 basis to receive either treatment with LYC-30937-EC or placebo. Subjects will be treated for 8 weeks, with an additional 2-week safety follow-up. The primary efficacy endpoint will be the proportion of subjects who achieve clinical remission at Week 8 using a modified Mayo score (MMS), while safety will be measured over 10 weeks. Continuation of treatment will be offered to participants in a separate open label extension study.
Lycera Announces Progress in Immuno-Oncology Program Presented at the 2016 American Association for Cancer Research Annual Meeting
Apr 19 16
Lycera Corp. announced that research findings from the Company's RORgamma agonist program were presented at this week's annual meeting of the American Association for Cancer Research (AACR), which is taking place in New Orleans, Louisiana, April 16-20, 2016. Lycera's synthetic RORgamma agonists increase the expression of co-stimulatory molecules, including CD226, CD27, and 4-1BB (CD137), and concomitantly decrease co-inhibitory molecules, including PD-1, TIGIT, and CD73. RORgamma agonists decrease PD-1 expression on CD4+ and CD8+ T cells after oral administration and on anti-tumor T cells in models of adoptive cell therapy. In addition, RORgamma agonist-mediated decreased PD-1 expression desensitizes cells to PD-L1 mediated inhibition of proliferation. In models of adoptive cell transfer, RORgamma agonists enhance persistence of anti-tumor effector T cells, reduce expression of exhaustion markers, and increase tumor-infiltrating lymphocytes (TILs).
Lycera Corp. Enters into License Agreement with Celgene Corporation
Jan 11 16
Lycera Corp. announced that it entered into a license agreement with its collaboration partner Celgene Corporation. Under the agreement, Lycera granted to Celgene an exclusive license for Lycera's portfolio of novel ex vivo RORgamma agonist compounds. Lycera is the leader in discovering and developing selective and potent oral agonists that target RORgamma, a master control switch of immune system activation, for the potential treatment of a broad range of cancers. While Lycera has developed orally bioavailable RORgamma agonists that have demonstrated single agent therapeutic activity in multiple animal models of cancer, ex vivo treatment with RORgamma agonist compounds has been shown to enhance the therapeutic benefit of adoptive T-cell therapy by improving both immune cell persistence and activation. Under the terms of the license agreement, Lycera received a $17.5 million upfront cash payment and has the potential to receive an additional near-term milestone payment of $5 million. In June 2015, Lycera and Celgene entered an exclusive global collaboration to take forward Lycera's proprietary product development pipeline for cancer and immune-mediated diseases. Key programs being advanced under this collaboration include LYC-30937 EC and Lycera's RORgamma agonists, as well as earlier-stage programs including a Rho-associated protein kinase 2 (ROCK2) inhibitor. As part of the strategic collaboration agreement, Celgene obtained the exclusive right to acquire Lycera upon conclusion of the option period or achievement by Lycera of pre-specified clinical milestones. During the option period, Lycera retains full control of its research and development programs. Following the exercise of the option to acquire Lycera, shareholders will also be eligible to receive future success-based milestones.
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