May 25, 2016 9:20 PM ET


Company Overview of Cardioxyl Pharmaceuticals, Inc.

Company Overview

Cardioxyl Pharmaceuticals, Inc., a clinical-stage pharmaceutical company, engages in the discovery and development of nitroxyl therapeutics for the treatment of cardiovascular diseases. It develops chemistry, biology, and clinical applications of nitroxyl technology; and provides CXL-1020, an initial nitroxyl donor clinical candidate for patients with acute decompensated heart failure. The company was founded in 2005 and is based in Chapel Hill, North Carolina. As of December 8, 2015, Cardioxyl Pharmaceuticals, Inc. operates as a subsidiary of Bristol-Myers Squibb Company.

1450 Raleigh Road

Exchange East

Suite 212

Chapel Hill, NC 27517

United States

Founded in 2005





Key Executives for Cardioxyl Pharmaceuticals, Inc.

Chief Executive Officer, President and Director
Scientific Co-Founder and Member of Scientific Advisory Board
Scientific Co-Founder, Member of Scientific Advisory Board and Member of Clinical Advisory Board
Scientific Co-Founder and Member of Scientific Advisory Board
Founder and Senior Vice President of Chemistry & Pre-Clinical Development
Compensation as of Fiscal Year 2015.

Cardioxyl Pharmaceuticals, Inc. Key Developments

Cardioxyl Pharmaceuticals, Inc. Announces Positive Results of Clinical Trial Demonstrating for Heart Failure Drug CXL-1427

Cardioxyl Pharmaceuticals, Inc. announced the positive results of a clinical trial demonstrating that CXL-1427, a novel potential treatment for acute decompensated heart failure (ADHF), was well tolerated in healthy volunteers. The company has now initiated dosing of hospitalized patients with decompensated heart failure in a Phase IIa clinical trial designed to further evaluate the drug's safety and tolerability as well as its dosing levels. The Phase I clinical trial evaluated the safety and tolerability of 24- and 48-hour continuous intravenous infusions of CXL-1427 in 80 healthy volunteers. The trial's results showed not only that CXL-1427 was well tolerated with limited adverse events, but also that it is clearly hemodynamically active. Cardioxyl's ongoing Phase IIa study is a randomized, double-blinded, placebo-controlled, invasive hemodynamic study designed to evaluate the safety, tolerability and hemodynamic effects of 6-hour intravenous infusions of CXL-1427 in hospitalized patients with advanced heart failure. It is being conducted at up to 34 clinical sites globally and will enroll approximately 48 hospitalized patients. Nitroxyl, the chemical name for HNO, has been studied for it's potential as a treatment for heart failure. HNO dilates blood vessels and acts directly on the heart through a unique mechanism to safely enhance both systolic and diastolic function. Cardioxyl's proprietary platform of HNO technology has produced a number of candidate therapeutics for treating heart failure, including CXL-1427.

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