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May 22, 2015 3:31 PM ET


Company Overview of Hydra Biosciences, Inc.

Company Overview

Hydra Biosciences, Inc., a biopharmaceutical company, engages in the identification and development of therapeutic agents that treat pain, inflammation, anxiety, renal, and pulmonary diseases. The company was founded in 2001 and is based in Cambridge, Massachusetts.

45 Moulton Street

Cambridge, MA 02138

United States

Founded in 2001





Key Executives for Hydra Biosciences, Inc.

Chief Executive Officer, President and Director
Age: 55
Scientific Co-Founder and Member of Scientific Advisory Board - Cardiac Regeneration
Scientific Co-Founder and Member of Scientific Avisory Board - Cardiac Regeneration
Scientific Co-Founder and Member of Scientific Advisory Board - Cardiac Regeneration
Interim Chief Financial Officer
Compensation as of Fiscal Year 2014.

Hydra Biosciences, Inc. Key Developments

Hydra Biosciences Receives Approval from Health Canada to Begin Phase 1 Trial for HX-100

Hydra Biosciences announced that Health Canada approved the company’s Clinical Trial Application (CTA) to begin a Phase 1 study of HX-100. This study will provide the safety data necessary for Phase 2 studies in painful diabetic neuropathy (PDN) and allergic asthma that are expected to begin later this year. TRP channels are membrane-bound proteins that play a role in controlling cellular calcium levels and excitability in response to a variety of stimuli. The 28 members of the TRP family differ from better-known ion channels in that they are not primarily voltage gated and have significant sequence diversity, providing the opportunity to develop truly selective modulators. In addition to their well-documented role in pain and pulmonary disorders, TRPs have been linked to CNS, renal and dermatological diseases. TRPA1 is a member of the TRP family, activated by reactive chemicals, products of aberrant glucose metabolism, tissue injury, and inflammation. Environmental irritants that lead to channel activity include common asthma triggers such as cigarette smoke, ozone and chlorine. HX-100 is a highly selective, potent inhibitor of TRPA1. Pre-clinical data demonstrate promising safety and efficacy with several potential advantages over currently available treatments for chronic pain and asthma. HX-100 can be taken orally, and it is expected to have robust efficacy without abuse liabilities, given the limited expression of TRPA1 in the brain. This Phase 1 trial of HX-100 follows a standard single ascending dose and multiple ascending dose design with approximately 90 healthy volunteers. The company expects to initiate separate Phase 2 studies in painful diabetic neuropathy and allergic asthma in late 2015 with results from these trials expected before the end of 2016.

Hydra Biosciences, Inc. and Boehringer Ingelheim Enter Research Collaboration Focused on Renal Diseases and Disorders

Hydra Biosciences, Inc. and Boehringer Ingelheim announced that they have entered into a worldwide research collaboration and license agreement to identify small-molecule TRP inhibitors, with a primary focus on the treatment of renal diseases and disorders. Under the terms of the collaboration agreement, the companies will work together to identify and advance candidate inhibitors. Boehringer Ingelheim is responsible for the global development and commercialization of the inhibitors that come from the collaboration. Hydra will receive an undisclosed upfront payment, additional research funding, and the company is eligible to receive milestone payments and tiered royalty payments on future product sales.

Hydra Biosciences, Inc. Presents at Needham & Company's 14th Annual Healthcare Conference, Apr-15-2015 10:40 AM

Hydra Biosciences, Inc. Presents at Needham & Company's 14th Annual Healthcare Conference, Apr-15-2015 10:40 AM. Venue: Westin Grand Central Hotel, New York, New York, United States. Speakers: Russell H. Herndon, Chief Executive Officer, President and Director.

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