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July 04, 2015 8:52 PM ET

Pharmaceuticals

Company Overview of AC Immune SA

Company Overview

AC Immune SA, a biopharmaceutical company, develops vaccines, antibodies, and small molecules for conformational diseases and cancer. The company develops active and passive immunotherapies against Alzheimer's disease using its molecular technology platform. It offers ACI-24, an Alzheimer's disease vaccine, which is designed to act as an active vaccine stimulating the patient's immune system to produce beta-sheet conformation-specific antibodies that prevent plaque deposition or enhance clearance of plaques; ACI-01-Ab7, a monoclonal antibody and passive immunotherapy; and Morphomers and ACI-91, the small molecules products. AC Immune SA was founded in 2003 and is based in Lausanne, Switzerla...

PSE Building B - EPFL

Lausanne,  1015

Switzerland

Founded in 2003

Phone:

41 21 693 91 21

Fax:

41 21 693 91 20

Key Executives for AC Immune SA

Co-Founder and Chief Executive Officer
Co-Founder and Member of the Scientific Advisory Board
Co-Founder
Chief Financial Officer
Chief Medical Officer
Compensation as of Fiscal Year 2015.

AC Immune SA Key Developments

AC Immune Seeks IPO

AC Immune SA is seeking an IPO. AC Immune will consider an initial public offering or a sale once its experimental Alzheimer’s treatment enters late-stage trials.

AC Immune (Switzerland) Enter into an Exclusive Global License and Research Agreement with Janssen Pharmaceuticals

AC Immune (Switzerland) has entered into an exclusive global license and research agreement with Janssen Pharmaceuticals, which is focused on the development and commercialization of anti-Tau therapeutic vaccines for the treatment of Alzheimer's disease and other tauopathies, such as frontotemporal dementia, progressive supranuclear palsy, and amyotrophic lateral sclerosis. Based on the terms of the transaction, AC Immune will receive an upfront payment, as well as potential research, development, and commercialization milestone payments worth up to CHF 500 million (USD 509 million). Janssen will be responsible for the development of AC Immune's lead therapeutic vaccine, ACI-35, following the Phase Ib completion for Alzheimer's disease, as well as a potential second indication outside of the disease. Janssen will also be responsible for manufacturing and commercialization of ACI-35. The agreement also involved a three-year co-research collaboration for the potential characterization and development of novel vaccines for tauopathies. AC Immune will be eligible for tiered royalties on net sales from products resulting from the collaboration.

AC Immune SA Enters into a Worldwide Exclusive License Agreement and Research Collaboration with Janssen Pharmaceuticals, Inc

AC Immune SA has entered into a worldwide exclusive license agreement and research collaboration with Janssen Pharmaceuticals, Inc. to develop and commercialize therapeutic anti-tau vaccines for the treatment of Alzheimer's disease and potentially other tauopathies. Janssen Research & Development, LLC will further develop the lead therapeutic vaccine, ACI-35, that is currently in a phase Ib clinical trial in Alzheimer's patients. ACI-35 is a therapeutic vaccine stimulating the patient's immune system to produce a polyclonal antibody response against phosphorylated tau protein. Under the terms of the agreement, AC Immune will receive an upfront payment and is eligible to receive research, development and commercialization milestone payments potentially totaling up to $509 million for Alzheimer's disease and a potential second indication outside of Alzheimer's disease. Additionally, AC Immune is eligible to receive tiered royalties on net sales for any approved products resulting from the collaboration. AC Immune and Janssen will co-develop ACI-35 through phase Ib completion. As of phase II and onward, Janssen will assume responsibility for the clinical development, manufacturing and commercialization of ACI-35. Additionally, AC Immune and Janssen Pharmaceuticals have entered a three year joint research collaboration to further characterize and develop novel vaccine therapies for the treatment of tauopathies.

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